{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:58:47Z","timestamp":1792033127738,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess halitosis parameters using OralChroma\u2122 and the correlation with salivary flow, oral hygiene index, radiation dose, and tongue\u2010coating index among irradiated head and neck cancer patients compared to patients without cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study enrolled irradiated and non\u2010irradiated patients divided into two groups. Hydrogen sulfide, methyl mercaptan, and dimethyl sulfide (DMS) levels were measured using a gas chromatograph, and sialometry was performed. The tongue\u2010coating index and simplified oral hygiene index were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010eight patients were allocated to each group. Volatile sulfur compound levels were above the thresholds in both groups. Non\u2010irradiated individuals showed higher levels of hydrogen sulfide and dimethyl sulfide. Patients with asialia had an inexpressive tongue\u2010coating index and increased dimethyl sulfide levels. A decrease in salivary flow rate was followed by a significant increase in volatile sulfur compound levels. Higher doses of radiation to the submandibular salivary glands were associated with higher concentrations of sulfide and methyl mercaptan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Head and neck radiotherapy may be important in the development of halitosis. Irradiated patients with asialia presented insignificant lingual biofilm. Consequently, lower levels of volatile sulfur compounds were detected in this group. Asialia, a severe radiation\u2010induced hyposalivation, impacted the levels of DMS (extraoral origin).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14225","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:25:52Z","timestamp":1651206352000},"page":"1836-1844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of halitosis parameters in patients undergoing head and neck radiotherapy"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5507-1824","authenticated-orcid":false,"given":"Gustavo Valerio","family":"Maluf","sequence":"first","affiliation":[{"name":"Department of Stomatology Bauru Dental School USP \u2013 University of Sao Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6410-0551","authenticated-orcid":false,"given":"Rog\u00e9rio Jardim","family":"Caldas","sequence":"additional","affiliation":[{"name":"Department of Dentistry Mario Kroeff Cancer Hospital  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-7631","authenticated-orcid":false,"given":"Eduardo Rodrigues","family":"Fregnani","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Hospital S\u00edrio\u2010Liban\u00eas  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1076-8019","authenticated-orcid":false,"given":"H\u00e9liton Spindola","family":"Antunes","sequence":"additional","affiliation":[{"name":"Clinical Research Division National Cancer Institute (INCA)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4150-4892","authenticated-orcid":false,"given":"Matheus Augusto Siscotto","family":"Tobias","sequence":"additional","affiliation":[{"name":"Department of Stomatology Bauru Dental School USP \u2013 University of Sao Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0674-3759","authenticated-orcid":false,"given":"Paulo S\u00e9rgio","family":"da Silva Santos","sequence":"additional","affiliation":[{"name":"Department of Stomatology Bauru Dental School USP \u2013 University of Sao Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2005.10.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e850"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752\u20107155\/5\/4\/046007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u20109668.107255"},{"key":"e_1_2_11_6_1","volume-title":"Medicina bucal","author":"Bag\u00e1n J. 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