{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:24:29Z","timestamp":1789759469949,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The use of autologous platelet concentrates has shown growing evidence as a promising therapy. We conducted a split\u2010mouth study to evaluate the effectiveness of injectable platelet\u2010rich fibrin (PRF) compared with triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This split\u2010mouth randomized trial included 12 patients with symptomatic, bilateral OLP lesions. The participants were randomly allocated to receive a 1\u2010ml intralesional PRF injection on one side of the buccal mucosa and a 0.5\u2010ml TA injection on the counterpart side. The application was performed once a week for 4\u2009weeks. The outcomes were measured using a visual analog scale score, REU score, and lesion areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both injectable TA and PRF were effective in the management of oral lichen planus. After 4\u2009weeks of treatment, there was an average reduction in the VAS score (68.5% i\u2010PRF, 91% TA) and an average reduction in the REU score (74% i\u2010PRF, 91% TA). There were no statistically significant differences between the two treatment methods (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intralesional injection with TA showed more effectiveness than i\u2010PRF in the management of OPL lesions. Although, i\u2010PRF cannot be considered a first\u2010line treatment option, it showed promising alternative therapy choice with no side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14261","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T08:24:55Z","timestamp":1653035095000},"page":"2256-2264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of injectable platelet\u2010rich fibrin in the treatment of symptomatic oral lichen planus"],"prefix":"10.1111","volume":"29","author":[{"given":"Noor","family":"Al\u2010Hallak","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, The Faculty of Dental Medicine Damascus University  Damascus 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