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MeSH terms and keywords were provided to examine only RCTs with antibiotic\u2010resistant results that included at least 3\u2009months of follow\u2010up of systematically healthy patients diagnosed with periodontitis and treated with systemic or local antibiotics adjunctive to subgingival debridement. RCTs that managed participants surgically, duplicate publications, and investigations implemented on animals were discarded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six RCTs were chosen. These studies included 465 patients. Most investigations observed that while\n                      <jats:italic>Aggregatibacter actinomycetemcomitans, Tannerella forsythia,<\/jats:italic>\n                      and\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      had low resistance to amoxicillin, microorganisms in many sites showed resistance to tetracycline, metronidazole, and azithromycin pretreatment.\n                      <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                      showed high resistance to tetracycline pre\u2010 and post\u2010therapy. The proportion of antibiotic\u2010resistant samples augmented rapidly after the prescription of antibiotics in all test groups. The percentage of antibiotic\u2010resistant microorganisms decreased over time; at the end of the follow\u2010up period, resistance levels were close to baseline levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjunctive local and systemic antibiotic treatment temporarily increased the antibiotic resistance of subgingival microorganisms; nonetheless, many bacteria remained susceptible to antibiotics during their administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14288","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T05:59:34Z","timestamp":1655963974000},"page":"2501-2511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Antibiotic resistance in periodontitis patients: A systematic scoping review of randomized 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