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One of the more unusual symptoms was patients' complaints of sudden loss of smell and\/or taste, a symptom that has become more apparent as the virus mutated into different variants. Anosmia and ageusia, the loss of smell and taste, respectively, seem to be transient for some individuals, but for others persists even after recovery from the infection. Causes for COVID\u201019\u2010associated chemosensory loss have undergone several hypotheses. These include non\u2010functional or destroyed olfactory neurons and gustatory receptors or of their supporting cells, disruption of the signaling protein Neuropilin\u20101, and disruption in the interaction with semaphorins, key molecules in the gustatory and olfactory axon guidance. The current paper will review these hypotheses and chart out potential therapeutic avenues.<\/jats:p>","DOI":"10.1111\/odi.14300","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T10:16:45Z","timestamp":1657016205000},"page":"2337-2346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chemosensory loss in\n                    <scp>COVID<\/scp>\n                    \u201019"],"prefix":"10.1111","volume":"28","author":[{"given":"Winnie","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Molecular Pathobiology New York University College of Dentistry  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9204-6513","authenticated-orcid":false,"given":"Gulshan","family":"Sunavala\u2010Dossabhoy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology LSU Health 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