{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:20:17Z","timestamp":1792686017524,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702694"],"award-info":[{"award-number":["81702694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872187"],"award-info":[{"award-number":["81872187"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141108"],"award-info":[{"award-number":["82141108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinicopathological characteristics, immunoprofile, and molecular alterations of adenoid cystic carcinoma (ACC) in children and young adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Twelve cases of ACC were included. MYB, MYBL1, Ki\u201067, type IV Collagen, Laminin, and LAMB1 expression were detected by immunohistochemistry.\n                      <jats:italic>MYB<\/jats:italic>\n                      and\n                      <jats:italic>MYBL1<\/jats:italic>\n                      rearrangements were detected by fluorescence in situ hybridization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 12 patients, four were female and eight were male. Seven cases (58.3%) located in major salivary glands and eight cases (66.7%) were classified as Grade I. Ten tumors (83.3%) had collagenous and hyalinized stroma. MYB was positive in 83.3% cases, and the average Ki\u201067 labeling index (LI) was 8.3%. LAMB1, type IV Collagen, and Laminin were positive in 91.7%, 66.7%, and 58.3% cases, respectively. Besides, three out of eight tumors had\n                      <jats:italic>MYB<\/jats:italic>\n                      rearrangement. Cases without\n                      <jats:italic>MYB<\/jats:italic>\n                      rearrangement were negative for MYBL1 expression and\n                      <jats:italic>MYBL1<\/jats:italic>\n                      rearrangement. The average follow\u2010up time was 91.8\u2009months. Four patients had recurrent diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ACC in children and young adults was seen more frequently in males and major salivary glands. Most cases had ECM and hyaline stroma. Grade III tumors, higher Ki\u201067 LI, negative expression of type IV Collagen, and Laminin showed a tendency of higher recurrence rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14311","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T03:19:07Z","timestamp":1657595947000},"page":"3289-3297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adenoid cystic carcinoma in children and young adults: A\u00a0clinicopathological study of 12 cases"],"prefix":"10.1111","volume":"29","author":[{"given":"Rong\u2010Hui","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai 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