{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:47:41Z","timestamp":1787748461401,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["STDF\u20105176"],"award-info":[{"award-number":["STDF\u20105176"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Zinc sulfide nanoparticles (ZnS NPs), as one of the quantum dots less than 10\u00a0nm, possess unique size\u2010dependent autofluorescence. Excitation of their valence electrons by energy higher than the bandgap reveals the ZnS NPs' inherited photocatalysis with additive cytotoxic consequences of reactive oxygen species (ROS) release. Coupling the cytotoxicity of photoactivated ZnS NPs with their autofluorescence would be a novel theranostic modality, combating superficially accessible carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>After synthesizing and characterization of ZnS NPs, we verified their photocatalysis and electron donation upon UV excitation in degrading organic dye and DNA cleavage, respectively. We then tested the efficacy of UV\u2010activated ZnS NPs to induce ROS\u2010dependent apoptosis in squamous cell carcinoma and breast cancer cell lines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The energetic electron\u2013hole pairs generated upon UV excitation of ZnS NPs with the consequent cascade of ROS release revealed potent apoptotic cancer cell deaths, compared with single treatment modalities of nonexcited nanoparticles and UV. Moreover, the inherited luminescence of ZnS NPs enabled visualization of their predominant intracytoplasmic uptake with tracking of their cellular response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The intensified luminescence and the fortified cytotoxicity of photoactivated ZnS NPs enhance their theranostic qualifications, boosting their antitumorigenic use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14324","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T12:51:00Z","timestamp":1658753460000},"page":"3243-3258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Photo\u2010excitable zinc sulfide nanoparticles: A theranostic nanotool for cancer management"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4781-4293","authenticated-orcid":false,"given":"Marwa M.","family":"Essawy","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dentistry Alexandria University  Alexandria Egypt"},{"name":"Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma T.","family":"Rafik","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8285-0188","authenticated-orcid":false,"given":"Ashraf K.","family":"Awaad","sequence":"additional","affiliation":[{"name":"Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine Alexandria University  Alexandria Egypt"},{"name":"Department of Biochemistry, Medical Research Institute Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada M.","family":"Mourad","sequence":"additional","affiliation":[{"name":"Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine Alexandria University  Alexandria Egypt"},{"name":"Department of Histology and Cell Biology, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-3585","authenticated-orcid":false,"given":"Samar N.","family":"El Achy","sequence":"additional","affiliation":[{"name":"Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine Alexandria University  Alexandria Egypt"},{"name":"Department of Pathology, Executive Manager of the Nanomedicine Laboratory at the Center of Excellence for Research in Regenerative Medicine (CERRMA), Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/joco.joco_29_20"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2020.137813"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn700176a"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43066\u2010020\u201000046\u20108"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"101","article-title":"Synthesis, characterization of ZnS nanoparticles by coprecipitation method using various capping agents\u2014Photocatalytic activity and kinetic study","volume":"6","author":"Ayodhya D.","year":"2013","journal-title":"Journal of Applied Chemistry"},{"issue":"6","key":"e_1_2_10_7_1","first-page":"1147","article-title":"Structural, microstructural and optical characterization of polyol\u2010mediated ZnS\/PVP nanocomposite powders and films","volume":"3","author":"Azib T.","year":"2012","journal-title":"Journal of Materials and Environmental Science"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1310193"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde\u20102018\u20100062"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/21691401.2015.1102739"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671\u2010017\u20102103\u2010z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20347"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2976"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13551"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22049"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2006.02.011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jctb.2264"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.200800406"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.5b11456"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(20)30215\u20101"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000488"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.307105064"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010015\u20100493\u20102"},{"issue":"4","key":"e_1_2_10_24_1","first-page":"75","article-title":"A brief review on photocatalytic activity of ZnS and CQDs nanoparticles","volume":"2","author":"Kaur S.","year":"2017","journal-title":"International Journal of Engineering Applied Sciences and Technology"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinp.2012.09.010"},{"issue":"5","key":"e_1_2_10_26_1","first-page":"613","article-title":"Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gastric mucosal lesions and mechanism of protection against oxidative stress\u2013induced gastric injury","volume":"65","author":"Kwiecien S.","year":"2014","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2016.06.008"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.626394"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21070920"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100985"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671\u2010017\u20102212\u20108"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9dt00989b"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13010171"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.19070\/2377\u20108075\u201020000238"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010014\u20100689\u2010z"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4an00294f"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804932115"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnano.2020.597382"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20010088"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx960037q"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.147"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11237\u2010016\u20109437\u2010y"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/179149"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102273"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131012242"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42452\u2010021\u201004643\u2010z"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.11.018"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/528047"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA13108E"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2016.2187"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876\u2010020\u201001772\u20100"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11434\u2010011\u20104694\u20106"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2010.12.006"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00131"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.6088\/ijaser.0020101029"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14195840"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja048650g"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.14324","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T08:44:04Z","timestamp":1721897044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.14324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/odi.14324"],"URL":"https:\/\/doi.org\/10.1111\/odi.14324","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.14324\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14324\/v2\/review2","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"assertion":[{"value":"2022-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}