{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:52Z","timestamp":1772160832730,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study examines the associations of active matrix metalloproteinase\u20108 (aMMP\u20108) point\u2010of\u2010care immunotest (Periosafe) outcomes with oral health of patients with haemato\u2010oncologic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients diagnosed with haematological diseases aimed to be treated with haematopoietic stem cell transplantation (HSCT) between 2018 and 2019 were included in the study. Clinical and radiological dental examination were taken immediately prior to transplantation. The presence of oral foci of infections, caries or periodontitis was examined and compared with the outcomes of aMMP\u20108 immunotest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Acute oral infection foci were present in 11.9%, chronic in 44.1% and periodontitis in 42.0% of the 143 subjects. aMMP\u20108 immunotest was positive in 13.3% of all the 143 subjects. Among subjects with periodontitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a060), the aMMP\u20108 immunotest was also positive in 13.3% of these subjects. However, the subjects with positive aMMP\u20108 immunotest (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019) had more often acute or chronic infection foci and more than one of the examined dental treatment needs compared with subjects with negative immunotest (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). There were no differences in age, sex, hyposalivation, DMFT\u2010index values nor with plasma levels of leukocytes, neutrophils or C\u2010reactive protein between subjects with positive or negative aMMP\u20108 immunotest.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>aMMP\u20108 immunotest accuracy might be reduced, in relation to periodontitis, in haemato\u2010oncologic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14335","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T10:14:16Z","timestamp":1659608056000},"page":"624-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral active matrix metalloproteinase\u20108 immunotest may be less accurate in haemato\u2010oncologic patients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-4939","authenticated-orcid":false,"given":"Matti","family":"Mauramo","sequence":"first","affiliation":[{"name":"Department of Pathology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Department for Oral Health &amp; Medicine UZB University Centre for Dental Medicine Basel UZB, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauliina","family":"Uutela","sequence":"additional","affiliation":[{"name":"Department for Oral Health &amp; Medicine UZB University Centre for Dental Medicine Basel UZB, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases Helsinki University Central Hospital, Institute of Dentistry  Helsinki Finland"},{"name":"Department of Oral Diseases Karolinska Institutet  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taina","family":"Tervahartiala","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases Helsinki University Central Hospital, Institute of Dentistry  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department for Oral Health &amp; Medicine UZB University Centre for Dental Medicine Basel UZB, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas","family":"Waltimo","sequence":"additional","affiliation":[{"name":"Department for Oral Health &amp; Medicine UZB University Centre for Dental Medicine Basel UZB, University of Basel  Basel 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