{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:07:36Z","timestamp":1785794856388,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH\u20102021\u2010C\u2010002"],"award-info":[{"award-number":["CSH\u20102021\u2010C\u2010002"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The theory of at least 2\u2010week waiting period between tooth extraction and head and neck radiotherapy could reduce osteoradionecrosis remains controversial. Thus, this study examined the theory and associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data were retrieved from the National Health Insurance Research Database, Taiwan Cancer Registry Database, and Cause of Death Statistics. We included 24,353 patients with head and neck cancer who received radiotherapy from 2011 to 2017 and were followed up until 2019. The patients were divided into three groups: those undergoing tooth removal 2\u20138\u2009weeks before radiotherapy, those undergoing tooth removal within 2\u2009weeks before radiotherapy, and others. Confounding factors were clinical information, physical conditions, and risky habits. We used the Cox regression model to assess osteoradionecrosis risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant difference in osteoradionecrosis risk was observed between those undergoing tooth extraction within 2\u2009weeks before radiotherapy and the other groups. An irradiation dose of \u226560\u2009Gy, chemotherapy, tumor excision, post\u2010radiotherapy tooth extraction, mandibulectomy, hyperlipidemia, and oral cavity as the tumor subsite were significantly positively associated with osteoradionecrosis risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A waiting period of \u22652\u2009weeks between tooth extraction and radiotherapy did not significantly reduce osteoradionecrosis risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14349","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T12:35:28Z","timestamp":1660221328000},"page":"575-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tooth extraction within 2\u2009weeks before radiotherapy and osteoradionecrosis: A nationwide cohort study"],"prefix":"10.1111","volume":"30","author":[{"given":"Yin\u2010Ju","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Dentistry Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"Department of Oral and Maxillofacial Surgery Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Medical Research Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Cheng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Asia University Hospital  Taichung Taiwan"},{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Mei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dentistry Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-7430","authenticated-orcid":false,"given":"Tsu\u2010Jen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Dentistry Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010Sen University  Kaohsiung Taiwan"},{"name":"School of Dentistry Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103410"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(69)90357-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.10.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.11.059"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102460"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21654"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12318"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-025359"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.05.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4087"},{"key":"e_1_2_10_13_1","unstructured":"Health Promotion Administration MoHaW T. 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