{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:16:54Z","timestamp":1790619414518,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We assessed the potential prognostic significance of the preoperative systemic inflammation index, platelet\u2010to\u2010lymphocyte ratio, and neutrophil\u2010to\u2010lymphocyte ratio in patients who underwent surgical resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 224 patients with clinicopathologically confirmed squamous carcinoma of the tongue who underwent surgery between August 2009 and December 2017. The optimal cut\u2010off values for the indices were determined by receiver operating characteristic curves. Correlations between the indices and clinicopathological variables were determined by Pearson chi\u2010square or Fisher exact tests. The Kaplan\u2013Meier test was used to compare overall survival between groups (high and low values); the log\u2010rank or Breslow test was used to assess differences in survival. Univariate and multivariate Cox regression models were used to analyze predictive values of the indices as independent indicators of overall survival. Bilateral\n                      <jats:italic>p<\/jats:italic>\n                      values of &lt;0.05 were considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant association was found between the indices and sex, tissue grade, tumor location, and lymph nodes metastases (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). On Kaplan\u2013Meier analysis, patients with lower values of the indices had longer overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Univariate and multivariate Cox regression models identified age, lymph node metastases, and neutrophil\u2010to\u2010lymphocyte ratio as independent predictors of overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The studied indices have potential prognostic significance in patients with squamous tongue cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14353","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T02:34:07Z","timestamp":1661135647000},"page":"187-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive value of systemic inflammatory response\u2010related indices for survival in tongue cancer"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-4368","authenticated-orcid":false,"given":"Liangbo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanbo","family":"Li","sequence":"additional","affiliation":[{"name":"School of Automation Science and Electrical Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanqi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenghao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-2112","authenticated-orcid":false,"given":"Xiaoyi","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"},{"name":"Medical School of Chinese PLA  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejun","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yipeng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6089-2202","authenticated-orcid":false,"given":"Haizhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28357"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71116-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26554"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S235519"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S338394"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2020.20.e18"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.189"},{"key":"e_1_2_10_9_1","first-page":"2553","article-title":"Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance","volume":"8","author":"Hoffmann T. 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