{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:39:42Z","timestamp":1791085182876,"version":"4.1.0"},"reference-count":128,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Periodontitis (PD) is one of the most common dental disorders. This chronic oral inflammation is caused by complicated interrelations between bacterial infections, dysregulated immune reactions, and environmental risk factors. A dysregulated immune response can lead to inflammatory bone resorption by allowing the recruitment of pro\u2010inflammatory immune cells to the periodontal tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>The recruitment of innate and adaptive immune cells in PD initiates the acute and following chronic inflammatory processes. The inflamed tissues, on the other hand, can be restored if the anti\u2010inflammatory lineages are predominantly established in the periodontal tissues. Therefore, we aimed to review the published literature to provide an overview of the existing knowledge about the role of immune cells in PD, as well as their possible therapeutic applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Experimental studies showed that drugs\/systems that negatively regulate inflammatory cells in the body, as well as interventions aimed at increasing the number of anti\u2010inflammatory cells such as Tregs and Bregs, can both help in the healing process of PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Targeting immune cells or their positive\/negative manipulations has been demonstrated to be an effective therapeutic method. However, to use this sort of immunotherapy in humans, further pre\u2010clinical investigations, as well as randomized clinical trials, are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14360","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T03:24:51Z","timestamp":1661397891000},"page":"2552-2564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The homeostasis and therapeutic applications of innate and adaptive immune cells in periodontitis"],"prefix":"10.1111","volume":"29","author":[{"given":"Li","family":"Junxian","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Shanxi Provincial People's Hospital  Taiyuan 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