{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:38:08Z","timestamp":1788824288078,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The significance of pre\u2010hemoglobin\u2010to\u2010platelet ratio (HPR) in predicting the occurrence of radiation\u2010induced trismus (RIT) in locally advanced nasopharyngeal carcinoma patients (LA\u2010NPC) who received concurrent chemoradiotherapy (C\u2010CRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The records of LA\u2010NPC patients with oral examination before and after C\u2010CRT were analyzed. Maximum mouth openings (MMO) were measured before and after C\u2010CRT to confirm RIT status, with an MMO of \u226435\u2009mm defined as RIT. HPR values were calculated on the first day of C\u2010CRT. The relationship between the HPR values and RIT status was discovered using the receiver operating characteristic curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 43 patients RIT cases among 198 individuals were diagnosed. The optimal HPR cutoff that stratified the patients into two groups was 0.54. RIT incidence was found to be significantly higher in the HPR \u22640.54 group than its HPR &gt;0.54 counterpart(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Univariately T\n                      <jats:sub>3\u20104<\/jats:sub>\n                      stage, mean masticator apparatus dose&gt;57.2Gy, and pre\u2010C\u2010CRT MMO \u226440.7\u2009mm were found as the other significant correlates of increased RIT rates(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). All four variables seemed to be independently connected to greater RIT incidence in multivariate analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, for each).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The risk of post\u2010C\u2010CRT RIT may be significantly increased when pre\u2010treatment HPR levels are low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14363","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T22:13:18Z","timestamp":1661811198000},"page":"2962-2970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hemoglobin\u2010to\u2010platelet ratio in predicting the incidence of trismus after concurrent chemoradiotherapy"],"prefix":"10.1111","volume":"29","author":[{"given":"Efsun","family":"Somay","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Baskent University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busra","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry Baskent University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8120-7123","authenticated-orcid":false,"given":"Erkan","family":"Topkan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine Baskent University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Kucuk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mersin City Hospital  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veysel","family":"Haksoyler","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Medline Hospital  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrin","family":"Pehlivan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Bahcesehir University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Selek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, School of Medicine Koc University  Istanbul Turkey"},{"name":"Department of Radiation Oncology, MD Anderson Cancer Center The University of Texas  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Araz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Baskent University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2019.02.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2019.05.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2006.04.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010012\u20100447\u20106"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010020\u201005630\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.24.1893"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.2008.00696.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010016\u20102461\u20103"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2005.08.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.04.003"},{"issue":"4","key":"e_1_2_10_13_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: Review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin S. 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