{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:38:46Z","timestamp":1777480726433,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870791"],"award-info":[{"award-number":["81870791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001008"],"award-info":[{"award-number":["82001008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cystathionine\u2010\u03b3\u2010lyase (CTH) has been proved to involve in inflammation and bone remolding, implying its potential role in the progression of periodontitis. This study was aimed to investigate the function of CTH and its relation to the macrophage polarization in periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Bone marrow\u2010derived macrophages (BMDMs) from wild\u2010type (WT) and\n                      <jats:italic>Cth<\/jats:italic>\n                      knockout (\n                      <jats:italic>Cth<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ) mice were stimulated with lipopolysaccharide (LPS) in vitro and pro\u2010inflammatory cytokines were analyzed by qRT\u2010PCR. Ligature\u2010induced periodontitis was established on WT and\n                      <jats:italic>Cth<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice. Histological analysis, tartrate\u2010resistant acid phosphatase staining, immunostaining, and Western blot were performed to analyze the periodontium destruction and M1 macrophage polarization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Cth<\/jats:italic>\n                      expression in BMDMs was upregulated upon increasing LPS stimulation. Deletion of\n                      <jats:italic>Cth<\/jats:italic>\n                      suppressed BMDMs inflammatory response with decreased\n                      <jats:italic>Il1b<\/jats:italic>\n                      ,\n                      <jats:italic>Il6<\/jats:italic>\n                      , and\n                      <jats:italic>Tnf<\/jats:italic>\n                      mRNA.\n                      <jats:italic>Cth<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice with periodontitis showed attenuated bone loss and impaired osteoclast differentiation compared with WT. Moreover,\n                      <jats:italic>Cth<\/jats:italic>\n                      knockout hindered M1 macrophage polarization, reduced the expression of IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 in periodontally diseased tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrated that CTH played an important role in regulating the inflammatory responses and periodontitis tissue destruction. Importantly,\n                      <jats:italic>Cth<\/jats:italic>\n                      knockout suppressed M1 macrophages polarization in periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14374","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T03:49:44Z","timestamp":1663040984000},"page":"769-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Weakening of\n                    <scp>M1<\/scp>\n                    macrophage and bone resorption in periodontitis cystathionine \u03b3\u2010lyase\u2010deficient mice"],"prefix":"10.1111","volume":"30","author":[{"given":"Sijin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthodontics Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai 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