{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:19:39Z","timestamp":1790961579638,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970937"],"award-info":[{"award-number":["81970937"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108010"],"award-info":[{"award-number":["82020108010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270976"],"award-info":[{"award-number":["82270976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202040458"],"award-info":[{"award-number":["202040458"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Innate lymphoid cells (ILCs) are vital innate immune cells cooperating with T cells. While their phenotypes and functions in oral mucosa kept unclear yet. In the present study, the relative proportions and distribution of different ILC subsets in oral mucosa of oral lichen planus (OLP), oral lichenoid lesions (OLL), and controls were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>\n                      Oral mucosal samples were collected from control (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a029), OLP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020), and OLL (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a022) donors. ILCs subsets were characterized in single\u2010cell suspensions by flow cytometry. Immunohistochemistry was performed to locate the CD127\n                      <jats:sup>+<\/jats:sup>\n                      cells in situ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ILCs were present in healthy and increased infiltration in OLP\/OLL (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0092,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0216). Infiltration of ILC1 increased in OLP\/OLL mucosa (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0225,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0399), as did the infiltration of ILC3 increase in OLL mucosa (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0128). The ILC2\/ILCs ratio was significantly reduced in OLP and OLL (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0124,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0346). CD127\n                      <jats:sup>+<\/jats:sup>\n                      cells were mainly located closely at the basement membrane.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of increased ILC1, decreased ILC2, and increased ILC3 suggested that changes of ILC distributions in oral mucosa may be relevant to persistent inflammation in local tissues, by promoting immune factors and weakening repair capacity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14384","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T07:03:52Z","timestamp":1664003032000},"page":"3372-3380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Group 1 and 3 innate lymphoid cells are increased in oral lichen planus and oral lichenoid lesions"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-1783","authenticated-orcid":false,"given":"Lei","family":"Pan","sequence":"first","affiliation":[{"name":"Department of 2nd Dental Center Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases College of Stomatology, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-5461","authenticated-orcid":false,"given":"Minghua","family":"Feng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases The Forsyth Institute, Harvard School of Dental Medicine Affiliate  Cambridge Massachusetts USA"},{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhe","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oral Science and Translational Research NSU College of Dental Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-1460","authenticated-orcid":false,"given":"Yufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-5613","authenticated-orcid":false,"given":"Guoyao","family":"Tang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases College of Stomatology, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Oral Medicine Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Stomatology Shanghai Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai 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