{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:47:00Z","timestamp":1790873220988,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["459672\/2014\u20102"],"award-info":[{"award-number":["459672\/2014\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["JCB0054\/2016"],"award-info":[{"award-number":["JCB0054\/2016"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the use of salivary biomarkers to identify psychological disorders (anxiety, depression, and stress) in individuals with oral lichen planus (OLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The search was made in Medline\/Pubmed, Scopus, Web of Science, Virtual Health Library, ProQuest, and by cross\u2010reference. Original case\u2013control, cross\u2010sectional, and cohort studies, in human subjects (age \u226518\u2009years) with clinical and histopathological diagnosis, with or without the use of psychometric scales, published until June 2021, were included. Random\u2010effects meta\u2010analyses, subgroup analyses, and sensitivity were performed. Publication bias was measured using the Egger test and visual inspection of the funnel plot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 67 articles were found, of which 12 were included in the meta\u2010analysis. Among the different biomarkers identified, it was only possible to perform a meta\u2010analysis for cortisol. The mean difference between salivary cortisol levels in patients with OLP compared to controls was 3.43\u2009ng\/ml (95% CI: 1.20\u20135.65) with\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a098.9%. Studies considered outliers were removed and based on sensitivity analyses, results did not change, therefore, being stable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The studies analyzed demonstrated that cortisol was the most quantified biomarker to identify psychological disorders; however, DHEA, IgA, adiponectin, and \u03b1\u2010amylase were also evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14385","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T23:58:20Z","timestamp":1664150300000},"page":"2734-2746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Salivary biomarkers to evaluate psychological disorders in oral lichen planus: A systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-8992","authenticated-orcid":false,"given":"Alessandra La\u00eds Pinho Valente","family":"Pires","sequence":"first","affiliation":[{"name":"Department of Health State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-8692","authenticated-orcid":false,"given":"L\u00edsia Daltro Borges","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Health State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-6970","authenticated-orcid":false,"given":"Adriana Mendon\u00e7a","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Health State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-9937","authenticated-orcid":false,"given":"Franco","family":"Arsati","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-2797","authenticated-orcid":false,"given":"Ynara Bosco de Oliveira","family":"Lima\u2010Arsati","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7225-5879","authenticated-orcid":false,"given":"Jean Nunes","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-265X","authenticated-orcid":false,"given":"Rodrigo Tripody","family":"Calumby","sequence":"additional","affiliation":[{"name":"Department of Exact Sciences State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7259-4827","authenticated-orcid":false,"given":"Val\u00e9ria Souza","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Health State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Psychological profile and unexpected pain in oral lichen planus: A case\u2013control multicenter SIPMO study a","author":"Adamo D.","year":"2021","journal-title":"Oral Diseases, 28, 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