{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:47Z","timestamp":1772160827919,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015549","name":"VNU Science and Technology Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872194"],"award-info":[{"award-number":["81872194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903045"],"award-info":[{"award-number":["81903045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072988"],"award-info":[{"award-number":["82072988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072990"],"award-info":[{"award-number":["82072990"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Accumulating studies have proved that the circular RNAs (circRNAs) play vital roles in human cancers. However, few circRNAs have been elucidated with lymph node metastasis. This study demonstrated that circ\u2010oral cancer metastasis\u2010associated circRNA (circ\u2010OMAC) is required to regulate the oral squamous cell carcinoma (OSCC) metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The circ\u2010OMAC were detected by circRNA\u2010sequencing and further verified by in situ hybridization (ISH). The role of circ\u2010OMAC was assessed by transwell assay and wound healing assay. Mechanistically, circ\u2010OMAC regulated OSCC metastasis by initiating the epithelial\u2010to\u2010mesenchymal transition (EMT) signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings suggested that circ\u2010OMAC was aberrantly elevated in the metastatic lymph nodes as compared to primary OSCC tissues. OSCC patients with high levels of circ\u2010OMAC were prone to a poor prognosis. By developing functional assays, we confirmed that circ\u2010OMAC promotes metastasis of OSCC cells via initiation of EMT pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We provide new insights whereby Circ\u2010OMAC as an oncogene is a potential therapeutic target and prognostic marker in oral cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14387","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T08:38:10Z","timestamp":1663835890000},"page":"140-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>Circ\u2010OMAC<\/scp>\n                    drives metastasis in oral squamous cell carcinoma"],"prefix":"10.1111","volume":"30","author":[{"given":"Bowen","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Oral and Maxillofacial Surgery Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shule","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Oral and Maxillofacial Surgery Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guokai","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Oral and Maxillofacial Surgery Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Ren","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Oral and Maxillofacial Surgery Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suling","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Oral and Maxillofacial Surgery Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou 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Sun Yat\u2010sen Memorial Hospital, Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Oral and Maxillofacial Surgery Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University  Guangzhou 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