{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:53:04Z","timestamp":1790873584928,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400494"],"award-info":[{"award-number":["81400494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our previous research have found that mesenchymal \u03b2\u2010catenin may be involved in palatal shelf (PS) elevation by regulating F\u2010actin. Here, we further investigated the exact mechanism of \u03b2\u2010catenin\/F\u2010actin in the PS mesenchyme to regulate palatal reorientation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      (1) Firstly, Ctnnb1\n                      <jats:sup>ex3f<\/jats:sup>\n                      (\u03b2\u2010catenin) mice were conditionally overexpressed in the palatal mesenchyme by crossing with the Sox9\u2010creER\n                      <jats:sup>T2<\/jats:sup>\n                      mice (induced by Tamoxifen injections); (2) Subsequently, histology and immunohistochemistry were used to characterize the variations of PS morphology and expression of key molecules associated with developmental process; (3) Finally, experiments in vivo and ex vivo were employed to identify the critical mechanisms in \u03b2\u2010catenin silenced and overexpressed models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that the Sox9CreER; Ctnnb1\n                      <jats:sup>ex3f<\/jats:sup>\n                      mice exhibited failed palatal elevation and visible cleft palate, and overexpression of \u03b2\u2010catenin disturbed the F\u2010actin responsible for cytoskeletal remodeling in palatal mesenchymal cells. qRT\u2010PCR results showed mRNA levels of \u03b1\u2010actinin4, a gene involved in F\u2010actin cross\u2010linking, were associated with knockdown or overexpression of \u03b2\u2010catenin in ex vivo, respectively. Experiments in vivo revealed that mesenchymal specific inactivation or overexpression of \u03b2\u2010catenin exhibited decreased or increased \u03b1\u2010actinin\u20104 expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mesenchymal \u03b2\u2010catenin\/F\u2010actin plays an essential role in PS reorientation, which mediate \u03b1\u2010actinin\u20104 to regulate F\u2010actin cytoskeleton reorganization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14408","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T12:16:23Z","timestamp":1666008983000},"page":"3493-3502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mesenchymal \u03b2\u2010catenin signaling affects palatogenesis by regulating \u03b1\u2010actinin\u20104 and F\u2010actin"],"prefix":"10.1111","volume":"29","author":[{"given":"Xiaoming","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate Surgery, West China School of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate Surgery, West China School of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate Surgery, West China School of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate Surgery, West China School of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate Surgery, West China School of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renkai","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate Surgery, West China School of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-9527","authenticated-orcid":false,"given":"Chenghao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate Surgery, West China School of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0962\u20108924(02)02404\u20102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.005132"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.067082"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.07.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476278.2019.1633871"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00392"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010020\u201000110\u20104"},{"key":"e_1_2_9_10_1","first-page":"555","article-title":"Palatal shelf elevation in the Wistar rat fetus","volume":"125","author":"Ferguson M. 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