{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:09:30Z","timestamp":1789322970339,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Compare recognized microscopic parameters, including variations in width, plaque\u2010like thickenings, intra\u2010epithelial microcysts, clefts, mucous, hob\u2010nail, ciliated and clear cells, between glandular odontogenic cyst (GOC) and GOC\u2010like cysts, investigate the extent of cyst circumference exhibiting these features, and inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Archival records of cysts with histological features of GOC evaluated between 2000 and2020 were retrieved. Slides were revised, and the expression of features throughout the cyst wall was analyzed. Cysts with at least 5 features were classified as GOC, cysts with 3\u20134 features as GOC\u2010like.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 74 cysts, 47 males M, 25 females (2 unknown gender), aged 19\u201381\u2009years, 62 (83.8%) GOC, 12 (16.2%) GOC\u2010like. Mandible was involved in 44 (59.5%), maxilla in 30 (40.5%), 18 (25%) were associated with unerupted teeth. Cyst classified as GOC had significantly higher rates of all parameters investigated, (except ciliated and clear cells), than GOC\u2010like cysts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05). 26 (40.6%) cases showed GOC features in &gt;50% of cyst circumference, 21 (32.8%) involved 25\u201350%, 17 (26.6%) &lt;25%. More than 50% circumference involvement was highly and independently predictive for a diagnosis of GOC, &lt;25% was highly and independently predictive for GOC\u2010like (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003). Hobnail cells (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008) and plaque\u2010like thickenings (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.038) were significantly more frequent in inflamed cysts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Besides the number and type of histological features, GOC can be characterized by their distribution within the cyst circumference (focal Vs diffuse), and it may serve as a new diagnostic aid. It is suggested that GOC and GOC\u2010like may represent a single spectrum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14415","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T04:16:23Z","timestamp":1666930583000},"page":"3306-3312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histopathological and histomorphometric analysis of glandular odontogenic\n                    <scp>cyst\u2010A<\/scp>\n                    diagnostic aid"],"prefix":"10.1111","volume":"29","author":[{"given":"Shimrit","family":"Heiliczer","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging Goldschleger School of Dental Medicine, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Shmuly","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Goldschleger School of Dental Medicine, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Unit of Oral and Maxillofacial surgery Kaplan Medical Center  Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gal","family":"Avishai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Goldschleger School of Dental Medicine, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center, Beilinson Hospital  Petach\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Zlotogorski\u2010Hurvitz","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging Goldschleger School of Dental Medicine, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery, Goldschleger School of Dental Medicine, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-2333","authenticated-orcid":false,"given":"Marilena","family":"Vered","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging Goldschleger School of Dental Medicine, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Mamber","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging Goldschleger School of Dental Medicine, Sackler Faculty of 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