{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:19:31Z","timestamp":1773685171180,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the link between pretreatment neutrophil\u2010to\u2010lymphocyte ratio(NLR) and the incidence of radiation\u2010induced trismus(RIT) in parotid gland cancers(PGC) patients after postoperative radiotherapy(PORT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Data of PGC patients who had oral examinations before and after PORT were reviewed retrospectively. We comprised patients who had maximum mouth opening (MMO) assessments before and after PORT and complete blood count test on the first day of PORT. MMO of \u226435\u2009mm was considered as RIT. The receiver operating characteristic (ROC) curve analysis was used to search for an ideal NLR threshold value that might be linked to RIT rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010one patients were included, with a RIT incidence of 15.7%. The NLR cutoff that showed a link with the prevalence of RIT in the ROC curve analysis was 2.7[Area under the curve (AUC):82.0%; sensitivity:87.5%; specificity:74.4%]. The patients were divided into groups based on this value:Group 1: NLR\u22642.7 (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a034) and;NLR\u2009&gt;2.7 (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a017). In comparative analysis, the incidence of RIT was found to be statistically higher in the NLR\u2009&gt;2.7 than counterpart (35.2%vs.5.8%;r\n                      <jats:sub>s<\/jats:sub>\n                      :0.79;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Also, a mean temporomandibular joint dose \u226551.0Gy was linked to increased RIT rates (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed that high pre\u2010PORT NLR levels were a robust and independent predictor of significantly elevated rates of RIT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14429","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T01:39:46Z","timestamp":1667957986000},"page":"2772-2779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Initial neutrophil\u2010to\u2010lymphocyte ratio predicts radiation\u2010induced trismus in parotid gland cancer"],"prefix":"10.1111","volume":"29","author":[{"given":"Efsun","family":"Somay","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Baskent University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busra","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Faculty of Dentistry Baskent University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8120-7123","authenticated-orcid":false,"given":"Erkan","family":"Topkan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine Baskent University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Kucuk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mersin City Hospital  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrin","family":"Pehlivan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Bahcesehir University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Selek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, School of Medicine Koc University  Istanbul Turkey"},{"name":"Department of Radiation Oncology MD Anderson Cancer Center, The University of Texas  Houston Texas 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