{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:35:41Z","timestamp":1790800541436,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish and test a clinician\u2010reported outcome measure of oral lichen planus (OLP): OLP Investigator global assessment (IGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>OLP IGA scale was tested with retrospective data from clinical practice and a phase II clinical trial. A comparison of the OLP IGA score with patient\u2010reported outcomes was completed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical Practice: The mean (SD) OLP IGA score (0\u20134) in 107 OLP patients was 1.8 (1.0) with correlation of 0.25\u20130.48 (<jats:italic>p<\/jats:italic> value 0.01 \u2013 &lt;0.0001) with symptom scores. There was a significant increase in OLP symptoms based on OLP IGA score.<\/jats:p><jats:p>Clinical Trial: The mean (SD) OLP IGA score in 137 research participants was 2.5 (1.2) with correlation of 0.43\u20130.52 (all <jats:italic>p<\/jats:italic> values &lt;0.0001) with symptoms scores. There was a significant increase in OLP symptoms based on OLP IGA score. Forty\u2010seven (35%) participants in the phase 2 study had an improvement in the OLP IGA score of \u22652. There were significant improvements in all symptoms scores in relation to the change in IGA score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The OLP IGA is designed to assess changes in symptomatic OLP lesions and is appropriate for use across the full range of symptomatic OLP severity and represents a scale with utility in clinical practice and clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14430","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T06:33:18Z","timestamp":1667975598000},"page":"3400-3407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral lichen planus clinician reported outcome measure: Development, content validity, and further development"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-4335","authenticated-orcid":false,"given":"Michael T.","family":"Brennan","sequence":"first","affiliation":[{"name":"Department of Oral Medicine\/Oral &amp; Maxillofacial Surgery Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"},{"name":"Department of Otolaryngology\/Head and Neck Surgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richeal Ni","family":"Riordain","sequence":"additional","affiliation":[{"name":"Oral Medicine Unit Cork University Dental School and Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Long\u2010Simpson","sequence":"additional","affiliation":[{"name":"Afyx Therapeutics  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bissonnette","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Oral &amp; Maxillofacial Surgery Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"},{"name":"Department of Stomatology, Faculty of Dentistry University of Montreal  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Lizano","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Oral &amp; Maxillofacial Surgery Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Siim","family":"Madsen","sequence":"additional","affiliation":[{"name":"Afyx Therapeutics  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13270"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13109"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2007.08106.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.21833"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100625.2001.100102.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.49.89"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.12.019"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.02.013"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2009.03562.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.1992.tb00974.x"},{"key":"e_1_2_12_12_1","unstructured":"United States Food and Drug Administration (FDA). (2009).Guidance for industry: patient\u2010reported outcome measures: use in medical product development to support labeling claims. Retrieved fromhttps:\/\/www.fda.gov\/downloads\/drugs\/guidances\/ucm193282.pdf"},{"key":"e_1_2_12_13_1","unstructured":"United States Food and Drug Administration (FDA). (2013).Roadmap to Patient\u2010Focused Outcome Measurement in Clinical Trials [Online]. Retrieved fromhttp:\/\/www.fda.gov\/downloads\/Drugs\/DevelopmentApprovalProcess\/DrugDevelopmentToolsQualificationProgram\/UCM370174.pdf"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13379"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.14430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T12:40:04Z","timestamp":1721911204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.14430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,21]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/odi.14430"],"URL":"https:\/\/doi.org\/10.1111\/odi.14430","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,21]]},"assertion":[{"value":"2022-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}