{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:24:48Z","timestamp":1790083488595,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the association between endodontic treatment failure and medication\u2010related osteonecrosis of the jaw (MRONJ) in a cohort of oncologic patients in therapy with antiresorptive and antiangiogenic drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients were selected as affected by MRONJ in absence of the common local risk factors (oral surgical procedures or ill\u2010fitting dentures) but showing failure of previous endodontic treatment performed at least 6\u2009months before the starting of antiresorptive\/antiangiogenic therapies. Jaw lesions were all surgically treated and patients underwent a strict clinical and radiological follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 18 patients, who developed 18 MRONJ, the only detectable local risk factor was the presence of teeth with failed endodontic treatment (more precisely, root canal underfilling in eight cases, root canal overfilling in two cases, root perforation in three cases, root fracture in five cases). All patients completely healed after surgical procedure and no recurrence was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Endodontic treatment failure should be considered a local risk factor for MRONJ development in oncologic patients. For such reason, it is mandatory to carefully evaluate them prior than the beginning of antiresorptive and antiangiogenic drugs administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14449","type":"journal-article","created":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T09:40:20Z","timestamp":1668937220000},"page":"2799-2805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Medication\u2010related osteonecrosis of the jaw triggered by endodontic failure in oncologic patients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-6292","authenticated-orcid":false,"given":"Angela","family":"Tempesta","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9819-6229","authenticated-orcid":false,"given":"Saverio","family":"Capodiferro","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Di Nanna","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences G. D'Annunzio University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5495-5660","authenticated-orcid":false,"given":"Marco","family":"Dolci","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences G. D'Annunzio University  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Scarano","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry G. 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