{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:28:13Z","timestamp":1788269293072,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060496"],"award-info":[{"award-number":["82060496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Accumulating evidence suggests that activated fibroblasts are the key cells in the T\u2010cell response to tumor immunosuppression. We attempted to investigate the effect of activated fibroblasts on PD\u2010L1 expression and the related immune escape mechanism in tongue squamous cell carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Western blotting, qPCR, and other techniques were used to study the expression of PD\u2010L1 in tongue squamous cell carcinoma cells and the nude mouse model of transplanted tumors in vivo; clinical tissue samples were verified. In addition, we established a direct coculture model of T cells and tongue squamous cell carcinoma cells explore the mechanisms of immune escape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that PDGF\u2010BB induces fibroblast activation by facilitating the oversecretion of chemokine CCL25. Further analysis showed that CCL25 derived from activated fibroblasts activated the Akt signaling pathway to promote PD\u2010L1 expression. The activated fibroblasts inhibited T\u2010cell IFN\u2010\u03b3 secretion through the CCL25\/Akt\/PD\u2010L1 pathway, which indirectly inhibited T\u2010cell proliferation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Activated fibroblasts can induce the high expression of PD\u2010L1 in the oral and tongue squamous cell carcinoma cell line Cal\u201027 via the CCL25\/CCR9\/p\u2010Akt axis, to significantly inhibit the proliferation and IFN\u2010\u03b3 secretion of T cells and promote the immune escape of tongue squamous cell carcinoma cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14455","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T02:15:18Z","timestamp":1669601718000},"page":"448-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Activated fibroblasts induce immune escape of\n                    <scp>TSCC<\/scp>\n                    through\n                    <scp>CCL25<\/scp>\n                    \/\n                    <scp>AKT<\/scp>\n                    pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Yiting","family":"Li","sequence":"first","affiliation":[{"name":"Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kunming Children's Hospital  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Periodontology The Affiliated Stomatological Hospital of Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Xu","sequence":"additional","affiliation":[{"name":"Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Oral Prevention Stomatological Hospital Affiliated to Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6621-4616","authenticated-orcid":false,"given":"Yongwen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dental Research The Affiliated Stomatological Hospital of Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"issue":"9","key":"e_1_2_9_2_1","first-page":"1132","article-title":"High PD\u2010L1 expression on tumor cells indicates worse overall survival in advanced oral squamous cell carcinomas of the tongue and the floor of the mouth but not in other oral compartments","volume":"9","author":"Adamski \u0141. 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