{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:37:56Z","timestamp":1792809476592,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the clinicopathological features, locoregional or distant metastasis, and prognosis of adenoid cystic carcinoma of submandibular gland (SMG\u2010AdCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinicopathological data of 80 patients with SMG\u2010AdCC from January 2005 to December 2017 were analyzed retrospectively, and the relationships between different parameters of SMG\u2010AdCC and its locoregional or distant metastasis or prognosis were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As of December 2019, 41 patients (51.25%) were tumor\u2010free, while 20 patients were found to be living with tumors. The locoregional metastasis rate of grade II\u2010III SMG\u2010AdCC were found to be significantly higher than that of grade I. The five\u2010year DFS and OS rates were 70.8% and 87.1%, respectively. Univariate analysis showed that clinical size, extraglandular extension, pathological grade, pathological node (pN) status, and perineural invasion were correlated with DFS. Multivariate Cox regression analysis showed that pathological grade and extraglandular extension were independent prognostic factors for DFS; pN status and extraglandular extension were independent prognostic factors impacting OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pathological grade is a risk factor for locoregional metastasis of SMG\u2010AdCC. Pathological grade, pN status, and status of extraglandular extension are independent prognostic factors for DFS\/OS in SMG\u2010AdCC patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14478","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T07:20:41Z","timestamp":1671866441000},"page":"1152-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adenoid cystic carcinoma of submandibular gland: Emphasis on locoregional metastasis and prognosis"],"prefix":"10.1111","volume":"30","author":[{"given":"Shengwen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong 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