{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:25:43Z","timestamp":1782818743931,"version":"3.54.5"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170947"],"award-info":[{"award-number":["82170947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is an inflammatory disease characterized by alveolar bone loss. Periodontal ligament stem cells (PDLSCs) have osteogenic differentiation potential, which can be influenced by epigenetics regulation in periodontitis. Therefore, this review aimed to shed light on the role of different epigenetic mechanisms in the osteogenic differentiation of PDLSCs and to consider the prospects of their possible therapeutic applications in periodontitis. Databases MEDLINE (through PubMed) and Web of Science were searched for the current knowledge of epigenetics in osteogenic differentiation of PDLSCs using the keywords \u201cperiodontal ligament stem cells\u201d, \u201cepigenetic regulation\u201d, \u201cepigenetics\u201d, \u201costeogenic differentiation\u201d, and \u201costeogenesis\u201d. All studies introducing epigenetic regulation and PDLSCs were retrieved. This review shows that epigenetic factors like DNMT, KDM6A, HDACi, some miRNAs, and lncRNAs can induce the osteogenic differentiation of PDLSCs in the noninflammatory microenvironment. However, the osteogenic differentiation of PDLSCs is inhibited in the inflammatory microenvironment through the upregulated DNA methylation of osteogenesis\u2010related genes and specific changes in histone modification and noncoding RNA. Epigenetics of osteogenic differentiation of PDLSCs in inflammation exhibits the contrary effect compared with a noninflammatory environment. The application of epigenetic drugs to regulate the abnormal epigenetic status in periodontitis and focus on alveolar bone regeneration is promising.<\/jats:p>","DOI":"10.1111\/odi.14491","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T05:53:06Z","timestamp":1672379586000},"page":"2529-2537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Epigenetic regulation of osteogenic differentiation of periodontal ligament stem cells in periodontitis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-1679","authenticated-orcid":false,"given":"Jingwei","family":"Cao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5039-4648","authenticated-orcid":false,"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-701X","authenticated-orcid":false,"given":"Mingmei","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29137"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12783"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114147"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12657"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071126"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2020.6239"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.2011.01392.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2017.2826"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3333"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21\u20100218"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520932491"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201812_16648"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12201"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26086"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010018\u20100484\u20102"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00248.2017"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509357411"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25429"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2017.0019"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes8080196"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12830"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13654"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.05.002"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2018.01.002"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13504"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12314"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010019\u20100614\u20104"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140559"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26542"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29780"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010018\u20100029\u20107"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.01.003"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201001953\u20108"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12009"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010019\u20101409\u20104"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102105"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27447"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010018\u20100025\u2010y"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6679708"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.112"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2016.0274"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.081"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133256"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.132"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010019\u20101546\u20109"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12888"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.276568.115"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.657825"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_92_18"},{"issue":"12","key":"e_1_2_12_51_1","first-page":"4030","article-title":"Improved biphasic calcium phosphate combined with periodontal ligament stem cells may serve as a promising method for periodontal regeneration","volume":"10","author":"Shi H.","year":"2018","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12221"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.7518\/hxkq.2019.01.020"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2019.0031"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2012.08.005"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.125"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1388"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12413"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.7518\/hxkq.2018.01.008"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.74"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.07.002"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28671"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515613043"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/972313"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.14491","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T17:52:49Z","timestamp":1696009969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.14491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":63,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/odi.14491"],"URL":"https:\/\/doi.org\/10.1111\/odi.14491","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,13]]},"assertion":[{"value":"2022-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}