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However, the topological properties of co\u2010occurrence networks of salivary and mucosal microbiome were different between healthy controls and OLP patients. SparCC analysis inferred three and five keystone taxa in the salivary and mucosal microbial networks of healthy controls, respectively. However, in the salivary and mucosal bacterial networks of OLP patients, only one hub OTU and three OTUs were identified as keystone taxa, respectively. In addition, analysis of community cohesion revealed that mucosal microbial community in OLP patients had lower stability than that in healthy controls. In final, correlation assay showed that the clinical severity of OLP was positively associated with the relative abundance of\n                      <jats:italic>Rothia<\/jats:italic>\n                      in saliva but negatively associated with that of\n                      <jats:italic>Porphyromonas<\/jats:italic>\n                      on mucosa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The salivary and mucosal bacterial communities of OLP patients differ in terms of composition, the genera associated with OLP severity, and co\u2010occurrence patterns.<\/jats:p>\n                  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