{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:54:45Z","timestamp":1788483285626,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T00:00:00Z","timestamp":1676764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify local radiographic risk factors for Medication\u2010Related Osteonecrosis of the Jaws (MRONJ) in osteoporotic patients treated with antiresorptive drugs (ARD) and undergoing tooth extraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Patients were included in this retrospective, longitudinal, case\u2010control study, if having at least one administration of ARD, underwent tooth extraction(s), and had pre\u2010 and post\u2010operative panoramic radiographs. Additionally, a matched control group was selected. Three calibrated, blinded, and independent observers assessed each tooth extraction site. Statistical analysis compared control against study group, and within the latter, sites MRONJ+ and MRONJ\u2212.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 120 patients (99 females\/21 males) with 354 tooth extractions were included, from which nine patients (7.5%) and eleven tooth extraction sites (3.1%) developed MRONJ. When comparing control with study group, the latter showed significantly more thickened lamina dura, persistence of the alveolar socket, heterogeneous bone patterns, and sequestrum formation. In the study group, MRONJ developed significantly more in males (19%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.049), smokers (25%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.008), in the mandible (82%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.027), when identifying a radiolucent or sclerotic trabecular pattern (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.004) or when extracting teeth with furcation involvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001), root remnants (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.017), or unrestored caries lesions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tooth extraction sites showing radiographic signs of chronic dental infection are prone to MRONJ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14496","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T02:59:36Z","timestamp":1673233176000},"page":"1632-1642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Local radiographic risk factors for\n                    <scp>MRONJ<\/scp>\n                    in osteoporotic patients undergoing tooth extraction"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-4355","authenticated-orcid":false,"given":"Catalina","family":"Moreno\u2010Rabi\u00e9","sequence":"first","affiliation":[{"name":"OMFS\u2010IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine University of Leuven  Leuven Belgium"},{"name":"Department of Oral and Maxillofacial Surgery University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-5022","authenticated-orcid":false,"given":"Hugo","family":"Ga\u00eata\u2010Araujo","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7803-4740","authenticated-orcid":false,"given":"Andr\u00e9","family":"Ferreira\u2010Leite","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Faculty of Health Sciences University of Bras\u00edlia  Brasilia 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