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Bone micro\u2010structure parameters was detected by micro\u2010CT, and FGF\u20101 and MMP\u20101 expression was examined by immunohistochemistry. Differentially expressed miRNAs of bilateral condyle cartilage were screened via miRNA microarray at 4\u2010 and 8\u2010week EUM, then further verified using quantitative reverse\u2010transcription PCR. Over\u2010expression of five differentially expressed miRNAs in chondrocytes was triggered by transfecting miRNA mimics. The expression of MMP\u201013, Col\u2010II, OPN, and Runx2 was verified by western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Expressions of FGF\u20101 and MMP\u20101 in right condyles gradually increased from 2 to 6\u2009weeks after EUM. A total of 20 differentially expressed miRNAs were regulated by EUM, which related to cell proliferation, invasion, and osteoblast differentiation pathways. The over\u2010expression of miR\u2010148a\u20103p and miR\u20101\u20103p led to down\u2010regulation of Col\u2010II, while MMP\u201013 and Runx2 were up\u2010regulated by induction of hypotrophic differentiation or IL\u20101\u03b2 stimulation. These findings suggested that miR\u2010148a\u20103p and miR\u20101\u20103p promote chondrogenic differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several pivotal miRNAs were found to be related to chondrogenic differentiation, which provides novel insight into pathogenic mechanisms of cartilage homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14504","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T10:04:15Z","timestamp":1673949855000},"page":"551-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of key mi\n                    <scp>RNA<\/scp>\n                    s in unilateral mastication\u2010induced disruption of cartilage 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