{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:00:00Z","timestamp":1791212400266,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epigenetic regulation plays important role in stem cell maintenance. Ptip was identified as epigenetic regulator, but the role in dental progenitor cells remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>\n                      Dental mesenchymal progenitor cells were targeted by\n                      <jats:italic>Sp7\u2010icre<\/jats:italic>\n                      and visualized in mTmG;\n                      <jats:italic>Sp7\u2010icre<\/jats:italic>\n                      mice. The\n                      <jats:italic>Ptip<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>f\/f<\/jats:italic>\n                      <\/jats:sup>\n                      ;\n                      <jats:italic>Sp7\u2010icre<\/jats:italic>\n                      mice were generated and the phenotype of incisors and molars were shown by micro\u2010computerized tomography, scanning electron microscope, hematoxylin &amp; eosin staining, and immunofluorescence. Dental mesenchymal progenitor cells were sorted by fluorescence\u2010activated cell sorting from lower incisors and RNA sequencing was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>Sp7\u2010icre<\/jats:italic>\n                      targets dental mesenchymal progenitor cells in incisors and molars. The\n                      <jats:italic>Ptip<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>f\/f<\/jats:italic>\n                      <\/jats:sup>\n                      ;\n                      <jats:italic>Sp7\u2010icre<\/jats:italic>\n                      mice showed spontaneous fractures in the cusp of upper incisors and lower incisors at 3\u2009weeks (w), compensative overgrowth of lower incisors at 1\u2009month (M), and overgrowth extended to the outside at 2\u00a0M. The molars showed shortened roots. The functions of odontoblasts and dental mesenchymal progenitor cells were impaired. Mechanically, loss of Ptip activates the Wnt pathway and upregulates the expression of\n                      <jats:italic>Wls<\/jats:italic>\n                      in dental mesenchymal progenitor cells. Also, the regenerative ability of lower incisors was significantly impaired.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We first demonstrated that Ptip was crucial for tooth development via regulating Wnt signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14509","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T10:10:23Z","timestamp":1673950223000},"page":"1451-1461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ptip is essential for tooth development via regulating Wnt pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Jianfei","family":"Liang","sequence":"first","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology, Xi'an Jiaotong 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