{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:00Z","timestamp":1772160840425,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Growing evidence exists about post\u2010COVID condition\/syndrome as sequelae of Sars\u2010CoV\u20102 infection in healed patients, possibly involving the lungs, brain, kidney, cardiovascular and neuromuscular system, as well the persistency of taste dysfunction. Such symptoms develop during or after infection and continue for more than 12\u2009weeks with pathogenesis related to virus persistency but variable by organs or systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We recently observed six patients recovered from COVID\u201019 and with negative RT\u2010PCR testing, showing oral mucosa lesions (mainly ulcers) overlapping those occurring in the acute phase, persisting up to 20\u2009days and thus needing a biopsy with histological investigation and spike protein evaluation by immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found epithelial ulceration, inflammatory infiltrate, vessels with increased diameter and flattened endothelium but no thrombi formation; also, we found a weak epithelial SARS\u2010CoV\u20102 positivity limited to the basal\/spinosum layers, progressively decreasing toward the periphery, and the intraepithelial lymphomonocytes, endothelium, and perivascular pericytes too.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings provide evidence that SARS\u2010CoV\u20102 can persist, as for other organs\/systems, also in the oral epithelium\/mucosa after the acute phase and can be responsible for lesions, although by a pathogenetic mechanism that should be better defined but certainly referable as the oral mucosa counterpart of post\u2010COVID syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14532","type":"journal-article","created":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T19:50:50Z","timestamp":1676231450000},"page":"1264-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral lesions with immunohistochemical evidence of Sars\u2010\n                    <scp>CoV<\/scp>\n                    \u20102 in swab\u2010negative post\u2010\n                    <scp>COVID<\/scp>\n                    syndrome"],"prefix":"10.1111","volume":"30","author":[{"given":"Luisa","family":"Limongelli","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Favia","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-5338","authenticated-orcid":false,"given":"Eugenio","family":"Maiorano","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Operating Unit of Pathological Anatomy Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-1201","authenticated-orcid":false,"given":"Antonio","family":"D'Amati","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Operating Unit of Pathological Anatomy Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Pispero","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical, and Dental Sciences University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Ingravallo","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, Operating Unit of Pathological Anatomy Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Barile","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-6292","authenticated-orcid":false,"given":"Angela","family":"Tempesta","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology Aldo Moro University  Bari 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