{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:46:56Z","timestamp":1793652416860,"version":"4.5.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202140504"],"award-info":[{"award-number":["202140504"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Non\u2010alcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized by excessive fat deposition in hepatocytes caused by non\u2010alcoholic liver injury.\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      (\n                      <jats:italic>P.g<\/jats:italic>\n                      ) is the main pathogen causing periodontitis, which can aggravate the progression of NAFLD in our previously study. The objective of this study was to further investigate the pathogenesis and moleculer michanisma of NAFLD aggravated by\n                      <jats:italic>P.g<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A mouse model of NAFLD was established, and the changes of inflammatory factors and NF\u2010\u03baB signaling pathway in liver tissue and L\u201002 cells were analyzed by transcriptome sequencing, Western blot, IHC and RT\u2010PCR. In addition, the NF\u2010\u03baB signaling pathway inhibitor QNZ and ferroptosis inhibitor Fer\u20101 were used to analyze the relationship between NF\u2010\u03baB signaling pathway and ferroptosis in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In vivo and in vitro experiments,\n                      <jats:italic>P.g<\/jats:italic>\n                      can induce liver inflammation and activate NF\u2010\u03baB signaling pathway. At the same time,\n                      <jats:italic>P.g<\/jats:italic>\n                      promotes ferroptosis and inflammation in L\u201002 in vitro. QNZ alleviates ferroptosis and inflammatory activation in L\u201002. Fer\u20101 can relieve the L\u201002 inflammation caused by\n                      <jats:italic>P.g products<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      can induce ferroptosis and inflammation in hepatocytes and further worsen liver lesions. The mechanism of ferroptosis in hepatocytes depends on NF\u2010\u03baB signaling pathway, which provides a new strategy for clinical treatment and prevention of NAFLD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14537","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T10:08:55Z","timestamp":1679306935000},"page":"1680-1694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<i>Porphyromonas gingivalis<\/i>\n                    triggers inflammation in hepatocyte depend on ferroptosis via activating the NF\u2010\u03baB signaling pathway"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-117X","authenticated-orcid":false,"given":"Chao","family":"Yao","sequence":"first","affiliation":[{"name":"Medical College Anhui University of Science and Technology  Huainan China"},{"name":"Department of 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