{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:25:08Z","timestamp":1775791508653,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to systematically review the clinicopathological data regarding foreign body reactions (FBR) related to esthetic procedures in the orofacial region. Electronic searches were performed in six databases and in gray literature using PEO acronym for the review question. Case series and case reports describing FBR related to esthetic procedures in the orofacial region were included. The JBI Critical Appraisal Checklist\u2013University of Adelaide tool was used for measuring the risk of bias. Eighty\u2010six studies reporting 139 cases of FBR were identified. The mean age at diagnosis was 54.12\u2009years (14\u201385\u2009years), with most of the cases reported in America, North America (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a042\/30.70%) and Latin America (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200933\/23.60%), mainly occurring in women (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0131\/94.40%). Asymptomatic (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a060\/43.40%) nodules (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a071\/50.60%) were the main clinical characteristics. The lower lip represented the most affected anatomical location (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a028\/22.20%), followed by the upper lip (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a027\/21.60%). Surgical removal was the treatment of choice (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a053\/35.70%). Twelve different dermal fillers were reported in the study, and the microscopic characteristics of the cases varied according to the material used. The results based on case series and case reports showed that nodule and swelling were the main clinical characteristics of FBR related to orofacial esthetic fillers. The histological characteristics depended on the type of the filler material used.\n                  <\/jats:p>","DOI":"10.1111\/odi.14541","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T09:13:32Z","timestamp":1676538812000},"page":"855-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Foreign body reactions related to orofacial esthetic fillers: A systematic review"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-6646","authenticated-orcid":false,"given":"Lucas Gon\u00e7alves","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-7651","authenticated-orcid":false,"given":"Lu\u00edsa Comerlato","family":"Jardim","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-936X","authenticated-orcid":false,"given":"Lauren Frenzel","family":"Schuch","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School Campinas University  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-5194","authenticated-orcid":false,"given":"Felipe Martins","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Molecular Pathology Area, School of Dentistry Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1447-2135","authenticated-orcid":false,"given":"Vivian Petersen","family":"Wagner","sequence":"additional","affiliation":[{"name":"Academic Unit of Oral and Maxillofacial Medicine and Pathology, Department of Clinical Dentistry University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-8878","authenticated-orcid":false,"given":"F\u00e1bio Ramos","family":"Pires","sequence":"additional","affiliation":[{"name":"Dental School Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7225-5879","authenticated-orcid":false,"given":"Jean Nunes Dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Bahia  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5965","authenticated-orcid":false,"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Department of Oral Diagnosis, Piracicaba Dental School Campinas University  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12374"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2008.01041.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010020\u201001190\u20108"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.04.020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010015\u20100135\u20107"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101220646"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16027"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445\u20102197.2010.05340.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01197-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.03.012"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820x13484492"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.18363\/rbo.v73n4.p.344"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.124459"},{"key":"e_1_2_11_15_1","volume-title":"Nanomedicine","author":"Freitas R. 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