{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:07:16Z","timestamp":1790482036308,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003356","name":"Gazi \u00dcniversitesi","doi-asserted-by":"publisher","award":["03\/07\u201016"],"award-info":[{"award-number":["03\/07\u201016"]}],"id":[{"id":"10.13039\/501100003356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The possible association between hypertension and periodontitis and the effect of hypertension on periodontal treatment were investigated by evaluating salivary and gingival crevicular fluid (GCF) interleukin (IL)\u20106 and C reactive protein (CRP) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010two healthy individuals without any previously diagnosed systemic disease [10 periodontally healthy (control) and 10 periodontitis (CP)] and subjects with hypertension [13 periodontally healthy (HP) and 9 with periodontitis (CP\u2009+\u2009HP)] participated in the study. GCF and saliva samples were obtained at baseline and 4\u2009weeks after Phase I periodontal treatment. Biochemical parameters were analyzed using ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Before the periodontal treatment, significantly higher GCF IL\u20106 and CRP levels were detected in CP\u2009+\u2009HP and CP groups compared to HP and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Salivary CRP level in CP\u2009+\u2009HP group was found to be higher than the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Statistically significant gingival and plaque index measurements (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) might suggest a possible effect of hypertension on periodontal status. Periodontal treatment significantly improved the clinical indices; however, biochemical parameters did not change after the treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The association of hypertension with periodontitis through local salivary and GCF inflammatory mediators might be possible in disease process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14543","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T02:11:11Z","timestamp":1676599871000},"page":"1622-1631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Interaction between hypertension and 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