{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:43Z","timestamp":1792686463644,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study evaluated the effect of resveratrol (RES) on the prevention of medication\u2010related osteonecrosis of the jaws (MRONJ) in ovariectomized (OVX) rats treated with zoledronate (ZOL). Fifty rats were distributed in five groups: SHAM (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010): non\u2010ovariectomy\u2009+\u2009placebo; OVX (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010):ovariectomy\u2009+\u2009placebo; OVX\u2009+\u2009RES (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010):ovariectomy\u2009+\u2009resveratrol; OVX\u2009+\u2009ZOL (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010):ovariectomy\u2009+\u2009placebo\u2009+\u2009zoledronate; and OVX\u2009+\u2009RES\u2009+\u2009ZOL (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010):ovariectomy\u2009+\u2009resveratrol\u2009+\u2009zoledronate. The mandibles left sides were analyzed with micro\u2010CT, histomorphometry, and immunohistochemistry. On the right side, bone markers gene expression was analyzed by qPCR. ZOL increased the percentage of necrotic bone and reduced the neo\u2010formed bone compared to groups not receiving ZOL (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). RES impacted the tissue healing pattern in OVX\u2009+\u2009ZOL\u2009+\u2009RES, reduced inflammatory cell infiltrate, and improved bone formation in the extraction site. Osteoblasts, alkaline phosphatase (ALP)\u2010, and osteocalcin (OCN)\u2010immunoreactive cells were lower in OVX\u2010ZOL than in SHAM, OVX, and OVX\u2010RES. The OXV\u2010ZOL\u2010RES had fewer osteoblasts and ALP\u2010 and OCN\u2010cells than the SHAM and OVX\u2010RES. The tartrate\u2010resistant acid phosphatase (TRAP)\u2010positive cells were reduced in the presence of ZOL (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), while the TRAP mRNA levels increased with ZOL treatment, with or without resveratrol, compared with the other groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). RES alone increased superoxide dismutase levels compared to OVX\u2009+\u2009ZOL and OVX\u2009+\u2009ZOL\u2009+\u2009RES (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In conclusion, resveratrol reduced the tissue impairment severity induced by ZOL; however, it could not prevent the occurrence of MRONJ.\n                  <\/jats:p>","DOI":"10.1111\/odi.14544","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T10:40:14Z","timestamp":1676889614000},"page":"1462-1474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Resveratrol for preventing medication\u2010related osteonecrosis of the jaws in rats"],"prefix":"10.1111","volume":"30","author":[{"given":"Marcelo","family":"Vitale","sequence":"first","affiliation":[{"name":"Dental Research Division, School of Dentistry Paulista University  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Grazieli","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Dental Research Division, School of Dentistry Paulista University  S\u00e3o Paulo 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