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One of the predominant functions of TJs is to regulate material transport through paracellular pathway, which serves as a selective barrier. In recent years, the expression and function of TJs in salivary glands has attracted great interest. The characteristics of multiple salivary gland TJ proteins have been identified. During salivation, the activation of muscarinic acetylcholine receptor and transient receptor potential vanilloid subtype 1, as well as other stimuli, promote the opening of acinar TJs by inducing internalization of TJs, thereby contributing to increased paracellular permeability. Besides, endothelial TJs are also redistributed with leakage of blood vessels in cholinergic\u2010stimulated submandibular glands. Furthermore, under pathological conditions, such as Sj\u00f6gren's syndrome, diabetes mellitus, immunoglobulin G4\u2010related sialadenitis, and autotransplantation, the integrity and barrier function of TJ complex are impaired and may contribute to hyposalivation. Moreover, in submandibular glands of Sj\u00f6gren's syndrome mouse model and patients, the endothelial barrier is disrupted and involved in hyposecretion and lymphocytic infiltration. These findings enrich our understanding of the secretory mechanisms that link the importance of epithelial and endothelial TJ functions to salivation under both physiological and pathophysiological conditions.<\/jats:p>","DOI":"10.1111\/odi.14549","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T03:53:40Z","timestamp":1677210820000},"page":"3-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The role and mechanism of tight junctions in the regulation of salivary gland secretion"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-1414","authenticated-orcid":false,"given":"Xin","family":"Cong","sequence":"first","affiliation":[{"name":"Center for Salivary Gland Diseases Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Di","family":"Mao","sequence":"additional","affiliation":[{"name":"Center for Salivary Gland Diseases Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Salivary Gland Diseases Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Department of Physiology and Pathophysiology Peking University School of Basic Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Salivary Gland Diseases Peking University School and Hospital of Stomatology &amp; National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735\u2010016\u20109667\u20102"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.02.023"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00165"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiologyonline.2001.16.3.126"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a002584"},{"key":"e_1_2_10_7_1","first-page":"213","article-title":"Neural regulation of blood flow in the rat submandibular gland","volume":"36","author":"Anderson L. 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