{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:12:17Z","timestamp":1775193137610,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate frequency of single nucleotide polymorphisms (SNPs) in pain\u2010related temporomandibular disorders (TMDp) and to determine whether specific SNPs, psychological, psychosomatic and behavioural characteristics are predictive for pain existence and intensity (low pain intensity (LPI)\/high pain intensity (HPI)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Genomic DNA was extracted from buccal mucosa swabs (85 TMDp;85 controls) for evaluating frequency of selected SNPs: catechol\u2010O\u2010methyltransferase (\n                      <jats:italic>rs4680<\/jats:italic>\n                      ,\n                      <jats:italic>rs4818<\/jats:italic>\n                      ), opiorphin (\n                      <jats:italic>rs1387964<\/jats:italic>\n                      ), alpha subunit of voltage\u2010gated sodium channel Nav1.1 (\n                      <jats:italic>rs6432860<\/jats:italic>\n                      ) and voltage\u2010gated sodium channel Nav1.9 (\n                      <jats:italic>rs33985936<\/jats:italic>\n                      ). Participants completed questionnaires on somatosensory amplification, anxiety and depression symptoms and oral behaviours (OB).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sleep\u2010related OB frequency was higher in TMDp patients compared to controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Compared to LPI, HPI patients had higher depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020) and anxiety scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). TMDp group showed higher frequency of CC genotype (\n                      <jats:italic>rs1387964<\/jats:italic>\n                      ) than controls (12.9% vs. 3.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025). Following adjustments for age, sex and sleep\u2010related OB, the significance of the recessive model (CC vs. TC\u2009+\u2009TT) between TMDp patients and controls was retained (OR\u2009=\u20095.783; 95%CI: 1.454\u201323.004). Frequency of GG genotype (\n                      <jats:italic>rs4680<\/jats:italic>\n                      and\n                      <jats:italic>rs4818<\/jats:italic>\n                      ) was higher in HPI compared to LPI patients (40% vs. 11.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006; 24% vs. 3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012, respectively). The difference remained significant after adjusting for age, sex, depression, anxiety and sleep\u2010related OB (\n                      <jats:italic>rs4680<\/jats:italic>\n                      : OR\u2009=\u20093.621; 95%CI: 1.580\u20138.297;\n                      <jats:italic>rs4818:<\/jats:italic>\n                      OR\u2009=\u20094.919, 95%CI: 1.641\u201314.746).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study has demonstrated that\n                      <jats:italic>rs1387964<\/jats:italic>\n                      CC genotype was associated with TMDp while\n                      <jats:italic>rs4680<\/jats:italic>\n                      GG and\n                      <jats:italic>rs4818<\/jats:italic>\n                      GG genotypes contributed to HPI.\n                    <\/jats:p>\n                  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