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Their toxic effects were tested by cell viability and blood chemistry analysis, meanwhile therapeutic effects were investigated in NOD mice in the aspects of saliva flow, histology, and immune cell distribution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Carbon quantum dots, with rich surface chemistry and unique optical properties, showed non\u2010cytotoxicity in vitro or no damage in vivo. Intravenously applied CQDs alleviated inflammation in the submandibular glands in NOD mice after 6\u2010week treatments. The inflammatory area index and focus score were significantly decreased in CQD\u2010treated mice. Besides, the levels of anti\u2010SSA and anti\u2010SSB were decreased in the presence of CQDs. The stimulated saliva flow rates and weight of submandibular glands were significantly increased in CQD\u2010treated mice by reducing the apoptosis of cells. The CD3\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells distributed around the ducts of submandibular glands were significantly decreased, while the percentage of Foxp3\n                      <jats:sup>+<\/jats:sup>\n                      cells was higher in CQD\u2010treated mice than that in the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that CQDs may ameliorate the dysregulated immune processes in NOD mice.<\/jats:p>\n                  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