{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:28:12Z","timestamp":1779888492088,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572663"],"award-info":[{"award-number":["81572663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602375"],"award-info":[{"award-number":["81602375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071125"],"award-info":[{"award-number":["82071125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum response factor (SRF) and myocardial\u2010associated transcription factor\u2010A (MRTF\u2010A) had different regulatory effects on the tumorigenesis and development in different cancers. However, the role of MRTF\u2010A\/SRF in oral squamous cell carcinoma (OSCC) remains to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CCK\u20108 assay, cell scratch experiment, and transwell invasion assay were conducted to investigate the effects of MRTF\u2010A\/SRF on biological behavior of OSCC cells. The expression pattern and prognostic value of MRTF\u2010A\/SRF in OSCC were analyzed based on cBioPortal website and TCGA database. Protein\u2013protein interaction network was visualized to identify protein functions. Go and KEGG pathway analyses were performed to investigate related pathways. The effect of MRTF\u2010A\/SRF on epithelial\u2013mesenchymal transformation (EMT) of OSCC cells was explored by western blot assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overexpression of MRTF\u2010A\/SRF inhibited the proliferation, migration, and invasion of OSCC cells in vitro. High expression of SRF was related to better prognosis of OSCC patients on hard palate, alveolar ridge, and oral tongue. Besides, overexpression of MRTF\u2010A\/SRF inhibited the EMT of OSCC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SRF was closely related to the prognosis of OSCC. High expression of SRF and its co\u2010activator MRTF\u2010A inhibited proliferation, migration, and invasion of OSCC cells in vitro, possibly via EMT suppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14611","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T06:51:46Z","timestamp":1683528706000},"page":"1919-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>MRTF\u2010A<\/scp>\n                    \/\n                    <scp>SRF<\/scp>\n                    signaling suppresses invasion of oral squamous cell carcinoma"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-5975","authenticated-orcid":false,"given":"Dan","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-9159","authenticated-orcid":false,"given":"Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University  Chengdu 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