{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:45:06Z","timestamp":1790671506160,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to evaluate the efficacy of high\u2010power (class IV) laser photobiomodulation (PBM) therapy for immediate pain relief due to oral mucositis (OM) refractory to recommended first\u2010line therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 25 cancer patients with refractory chemotherapy\u2010 or radiotherapy\u2010induced OM (16 and 9 patients, respectively) that were treated for pain relief with an intraoral InGaAsP diode laser (power density\u2009=\u20091.4\u2009W\/cm<jats:sup>2<\/jats:sup>). Pain was self\u2010assessed immediately before and after laser treatment using a 0\u2010to\u201010 numeric rating scale ([NRS], \u201c0\u201d\u2009=\u2009no pain, \u201c10\u201d\u2009=\u2009intolerable pain).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients reported an immediate decrease in pain following 94% (74 of 79) of the PBM sessions, in 61% (48 sessions) the pain reduction was over 50%, and in 35% (28 sessions) the initial pain was completely eliminated. There were no reports of increased pain post\u2010PBM. For chemotherapy and radiotherapy\u2010treated patients, mean reduction in pain NRS post\u2010PBM was 4.8\u2009\u00b1\u20092.5 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 4.5\u2009\u00b1\u20092.8 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), indicating a post\u2010PBM reduction of 72% and 60% of the initial pain level, respectively. The analgesic benefit of PBM remained for a mean of 6.0\u2009\u00b1\u20095.1\u2009days. One patient reported a transient burning sensation after one PBM session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010power laser PBM may provide nonpharmacologic, patient\u2010friendly, long\u2010lasting, rapid pain relief for refractory OM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14618","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T08:49:11Z","timestamp":1684486151000},"page":"2285-2292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>High\u2010power<\/scp> laser photobiomodulation therapy for immediate pain relief of refractory oral mucositis"],"prefix":"10.1111","volume":"30","author":[{"given":"Ori","family":"Finfter","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Sedation and Maxillofacial Imaging Hebrew University\u2013Hadassah School of Dental Medicine  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refael","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Sedation and Maxillofacial Imaging Hebrew University\u2013Hadassah School of Dental Medicine  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiham","family":"Hanut","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Sedation and Maxillofacial Imaging Hebrew University\u2013Hadassah School of Dental Medicine  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach","family":"Gavish","sequence":"additional","affiliation":[{"name":"Institute for Research in Military Medicine Department of Military Medicine and \"Tzameret\", Faculty of Medicine The Hebrew University of Jerusalem and Israel Defense Forces Medical Corps  Jerusalem Israel"},{"name":"The Saul and Joyce Brandman Hub for Cardiovascular Research and the Department of Medical Neurobiology, Institute for Medical Research (IMRIC), Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-6529","authenticated-orcid":false,"given":"Yehuda","family":"Zadik","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Sedation and Maxillofacial Imaging Hebrew University\u2013Hadassah School of Dental Medicine  Jerusalem Israel"},{"name":"Institute for Research in Military Medicine Department of Military Medicine and \"Tzameret\", Faculty of Medicine The Hebrew University of Jerusalem and Israel Defense Forces Medical Corps  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.47750\/pnr.2023.14.S01.02"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010016\u20101975\u2010y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2018.4600"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.05.018"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23573"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3582"},{"key":"e_1_2_12_8_1","unstructured":"Biolase I.(2018).EpicX user manual. 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