{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:38:16Z","timestamp":1791574696709,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this cross\u2010sectional study was to show relations between activity impairment and salivary gland involvement for patient empowerment in primary Sjogren's syndrome (pSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the study, 86 patients with pSS were included. The data were collected through clinical examinations and a questionnaire regarding Work Productivity and Activity Impairment (WPAI), EULAR Sjogren's syndrome patient\u2010reported index (ESSPRI) and Oral Health Impact Profile\u201014 (OHIP\u201014). Relations were analysed by using mediation and moderation analyses. In simple mediation analysis, an independent variable (X) influences outcome variable (Y) through a mediator variable (M) whereas a moderator variable (W) affects the direction of the relationship between the dependent (Y) and independent variables (X).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increases in ESSPRI\u2010Dryness score (X) (<jats:italic>p<\/jats:italic>\u2009=\u20090.0189) and OHIP\u201014 score (M) (<jats:italic>p<\/jats:italic>\u2009=\u20090.0004) were associated with the poor WPAI activity impairment score (Y) in the first mediation analysis. The WPAI activity impairment score was mediated by the elevated ESSPRI\u2010Fatigue score (X) (<jats:italic>p<\/jats:italic>\u2009=\u20090.03641) and low U\u2010SFR (M) (<jats:italic>p<\/jats:italic>\u2009=\u20090.0000) in the second mediation analysis. In addition, ESSPRI\u2010Pain score (W) was the significant moderator for WPAI activity impairment (Y) in patients without hyposalivation in the moderation analysis (<jats:italic>p<\/jats:italic>\u2009=\u20090.0010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WPAI activity impairment was affected by both ESSPRI\u2010Dryness with OHRQoL and ESSPRI\u2010Fatigue with SFR in glandular involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14620","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T13:37:50Z","timestamp":1685367470000},"page":"2234-2244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A cross\u2010sectional study on activity impairment in primary Sjogren's syndrome"],"prefix":"10.1111","volume":"30","author":[{"given":"Y\u0131ld\u0131z","family":"Yenissoy","sequence":"first","affiliation":[{"name":"Institute of Health Sciences Marmara 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