{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:12:29Z","timestamp":1773346349191,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this systematic review and meta\u2010analysis of observational studies was to assess whether herpes simplex virus type 1 (HSV\u20101) can infect endodontic periapical lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Studies with cross\u2010sectional design investigating HSV\u20101 in periapical tissues of patients with symptomatic and asymptomatic acute and chronic apical periodontitis were searched through MEDLINE, Scopus, Embase, Web of Science, and Google Scholar. Pooled HSV\u20101 prevalence proportion with 95% confidence interval (95CI) in periapical lesions was assessed with both fixed\u2010effect and random\u2010effects models, with\/without adjustment for study quality and publication bias. Result robustness was investigated through sensitivity and subgroup analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Literature search, performed twice, provided 84 items, and eight remained for the meta\u2010analysis; globally, there were 194 patients mostly adults. The pooled HSV\u20101 prevalence proportions, assessed with various methods, were 6.9% (95CI, 3.8\u201311.3%, fixed\u2010effect); 6.8% (95CI, 3.6\u201311.0%, random\u2010effects); 8.1% (95CI, 4.4\u201314.5%, quality\u2010adjusted); and 4.8% (95CI, 2.0\u201311.4%; adjusted for small\u2010study effect).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results indicated that HSV\u20101 can colonize the periapical tissues of 3%\u201311% patients with periapical diseases. Such data do not imply a causative role of HSV\u20101 in disease development and advancement. Well\u2010designed and large\u2010sized prospective cohort studies should be added in the literature panorama.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14645","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T07:40:35Z","timestamp":1687246835000},"page":"865-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Herpes simplex virus type 1 in periapical pathoses: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Paolo G.","family":"Arduino","sequence":"first","affiliation":[{"name":"Department of Surgical Science, CIR\u2010Dental School University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2523-8149","authenticated-orcid":false,"given":"Mario","family":"Alovisi","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, CIR\u2010Dental School University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-8860","authenticated-orcid":false,"given":"Stefano","family":"Petti","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Disease Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12029"},{"key":"e_1_2_10_3_1","unstructured":"American Association of Endodontists. 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