{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:55:56Z","timestamp":1787313356900,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Submucosal fibrosis (OSF) of the oral cavity is a chronic scarring disease. Arecoline (Are) is the driving factor for the occurrence and deterioration of OSF. Curcumin plays a vital anti\u2010inflammatory role in Are\u2010induced OSF development. However, its potential pharmacological mechanism needs to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The relative molecular level was measured via qRT\u2010PCR or Western blot. MTT assay, transwell assay and flow cytometry detected cell proliferation, migration, and apoptosis. The correlation between hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) and LTBP2 promoter was confirmed through dual\u2010luciferase reporter assay. ELISA was performed to detect inflammatory cytokines levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Curcumin alleviated Are\u2010induced oral mucosal fibroblast cells fibrosis by reducing oral mucosa fibroblasts viability, promoting cell apoptosis, suppressing cell migration, and down\u2010regulating the levels of fibrosis markers and inflammatory factors. Curcumin relieved Are\u2010induced OSF via inhibiting HIF\u20101\u03b1. Mechanically, HIF\u20101\u03b1 bound to the promoter of LTBP2 to transcriptionally activated LTBP2. LTBP2 knockdown relieved Are\u2010induced OSF, and curcumin down\u2010regulated LTBP2 via inhibiting HIF\u20101\u03b1 to relieve Are\u2010induced OSF. Moreover, curcumin decreased NF\u2010\u03baB signal associated proteins via inhibiting LTBP2 to relieve Are\u2010induced OSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Curcumin reduced the transcription level of LTBP2 by inhibiting HIF\u20101\u03b1, thereby inactivating NF\u2010\u03baB pathway to alleviate Are\u2010induced OSF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14656","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T09:15:14Z","timestamp":1688030114000},"page":"2314-2324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Curcumin relieves arecoline\u2010induced oral submucous fibrosis via inhibiting the\n                    <scp>LTBP2<\/scp>\n                    \/\n                    <scp>NF\u2010\u03baB<\/scp>\n                    axis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0684-6851","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mang","family":"Luo","sequence":"additional","affiliation":[{"name":"Hunan Changsha Maternal and Child Health Hospital  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/njms.njms_324_21"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008209809002444"},{"key":"e_1_2_10_4_1","article-title":"Effect of curcumin against oxidation of biomolecules by hydroxyl radicals","volume":"8","author":"Borra S. 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