{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:05Z","timestamp":1772160845403,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173326"],"award-info":[{"award-number":["82173326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972542"],"award-info":[{"award-number":["81972542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073000"],"award-info":[{"award-number":["82073000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Investigating T\u2010cell immunoglobulin and mucin\u2010domain containing\u20103 (TIM\u20103), Galectin 9 (Gal\u20109), CD160 expression and tumor\u2010infiltrating lymphocytes (TILs) and correlation with clinicopathological characteristics of salivary adenoid cystic carcinoma (SACC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty cases of SACC were detected by immunohistochemical staining to evaluate TIM\u20103, Gal\u20109, and CD160 expression and analyze the correlation between TIM\u20103, Gal\u20109, CD160 expression and clinicopathologic features by rank\u2010sum test. The association of TILs with TIM\u20103, Gal\u20109, and CD160 expression in SACC stromal was done by Chi\u2010square test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TIM\u20103 and CD160 overexpression were correlated with recurrence of SACC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007, respectively). High Gal\u20109 expression was correlated with pathological classification (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). The average percentage of TILs was 18.2% in SACC and most of TILs were more likely to occur in minor salivary glands (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). Pairwise positive correlations were observed between the expression of TIM\u20103, Gal\u20109, and CD160 in tumor cells as well as in TILs, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low density of TILs was characteristic of the SACC microenvironment, with upregulation of TIM\u20103, Gal\u20109, and CD160 all occurring. However, TIM\u20103, Gal\u20109, and CD160 expression in the stromal dependent on the number of TILs represent potential therapeutic targets in SACC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14666","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T03:01:02Z","timestamp":1689562862000},"page":"2262-2274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>TIM<\/scp>\n                    \u20103\/Galectin\u20109 and\n                    <scp>CD160<\/scp>\n                    expression in salivary adenoid cystic carcinoma"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-9970","authenticated-orcid":false,"given":"Mao","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Pathology, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010xin","family":"Wan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Pathology, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010yang","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Pathology, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-3658","authenticated-orcid":false,"given":"Xin\u2010hua","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-3571","authenticated-orcid":false,"given":"Ya\u2010ling","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Pathology, West China Hospital of Stomatology Sichuan University  Chengdu 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