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This study aimed to determine whether IL17RB correlates with oral cancer and promotes oral cancer progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>IL17RB expression in oral cancer tissues and normal tissues was determined by immunohistochemistry staining, while the association of IL17RB expression with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC) patients was analyzed and its correlation with progression\u2010free survival and response to radiotherapy and chemotherapy in OSCC patients was also explored. Western blotting was performed to investigate the expression of IL17RB in various OSCC cell lines; moreover, transwell assay was performed to evaluate the effect of IL17RB expression on cell migration ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this study, we found that IL17RB was expressed higher in OSCC tissues compared to normal oral mucosa tissues and its expression was positively correlated with tumor size, lymph node metastasis, advanced cancer stage, and poor prognosis. In vitro study showed that IL17RB expression in OSCC cell lines as determined by Western blotting, was positively correlated with their migration ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinical and in vitro studies suggest that IL17RB might serve as an independent risk factor and a therapeutic target for oral cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14672","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T02:16:58Z","timestamp":1689301018000},"page":"2027-2038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4753-788X","authenticated-orcid":false,"given":"Shyng\u2010Shiou F.","family":"Yuan","sequence":"first","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Translational Research Center Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Obstetrics and Gynecology Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Medical Research Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Drug Development and Value Creation Research Center Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Wei","family":"Su","sequence":"additional","affiliation":[{"name":"Drug Development and Value Creation Research Center Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Dentistry, College of Dental Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Division of Oral and Maxillofacial Surgery Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leong\u2010Perng","family":"Chan","sequence":"additional","affiliation":[{"name":"Cohort Research Center Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Kaohsiung Municipal Ta\u2010Tung Hospital and Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hieu D. 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