{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:06:08Z","timestamp":1788973568028,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to observe the effect of acupuncture on regulating interleukin (IL)\u201017, tumor necrosis factor (TNF)\u2010\u0251, and aquaporins (AQPs) in Sj\u00f6gren's syndrome (SS) on patients and on non\u2010obese diabetic (NOD) models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Levels of anti\u2010AQP 1, 5, 8, and 9 antibodies, IL\u201017, and TNF\u2010\u0251 in the serum of SS patients were compared prior and following 20 acupuncture treatment visits during 8\u2009weeks. While in murine model, five groups were divided to receive interventions for 4\u2009weeks, including control, model, acupuncture, isoflurane, and hydroxychloroquine. The submaxillofacial gland index, histology, immunohistochemistry of AQP1, 5, salivary flow, together with IL\u201017, and TNF\u2010\u0251 expression in peripheral blood were compared among the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acupuncture reduced IL\u201017, TNF\u2010\u0251, and immunoglobin A levels, and numeric analog scale of dryness in 14 patients with SS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The salivary flow was increased, and the water intake decreased in NOD mice receiving acupuncture treatments. IL\u201017 and TNF\u2010\u0251 levels in peripheral serum were down\u2010regulated (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and AQP1, 5 expression in the submandibular glands up\u2010regulated in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The effect on relieving xerostomia with acupuncture may be achieved by up\u2010regulating the expression of AQP1. AQP5, down\u2010regulating levels of IL\u201017 and TNF\u2010\u0251, and a decrease in inflammation of glands.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14680","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T05:10:05Z","timestamp":1690780205000},"page":"50-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of acupuncture on regulating <scp>IL<\/scp>\u201017, <scp>TNF<\/scp>\u2010\u0251 and <scp>AQPs<\/scp> in Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-0175","authenticated-orcid":false,"given":"Ruihua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rheumatology Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing 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