{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:07Z","timestamp":1772160847055,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660187"],"award-info":[{"award-number":["81660187"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of key pathogenic genes involved in the development of jaw ameloblastoma (AB) and its associated extracellular matrix (ECM) on osteogenic differentiation in order to provide a theoretical foundation for future research into bone aggressiveness of AB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The essential genes were identified by five AB patients for whole\u2010exome sequencing and the microarray datasets GES38494 and GES132472. Moreover, the expression of key genes and their encoded proteins in AB tissues was explored. In addition, AB\u2010derived the decellularized ECM (ABdECM) tissues were generated by the decellularization technique. Furthermore, the osteogenic development of periodontal ligament stem cells (PDLSCs) was mimicked by simulating the effects of the AB tumor microenvironment (TME).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The AB essential genes including\n                      <jats:italic>COL1A2<\/jats:italic>\n                      ,\n                      <jats:italic>COL4A2<\/jats:italic>\n                      ,\n                      <jats:italic>FBN1<\/jats:italic>\n                      , and\n                      <jats:italic>HPSE<\/jats:italic>\n                      were discovered. Among them, the expression of\n                      <jats:italic>HPSE<\/jats:italic>\n                      \u00a0was down\u2010regulated, while that of\n                      <jats:italic>COL1A2<\/jats:italic>\n                      ,\n                      <jats:italic>COL4A2<\/jats:italic>\n                      , and\n                      <jats:italic>FBN1<\/jats:italic>\n                      was noticeably upregulated in AB compared with normal gingival tissues of the jaws. In vitro osteogenic differentiation of PDLSCs was suppressed by the ABdECM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Abnormal ECM proteins encoded by\n                      <jats:italic>COL4A2<\/jats:italic>\n                      ,\n                      <jats:italic>COL1A2<\/jats:italic>\n                      ,\n                      <jats:italic>FBN1<\/jats:italic>\n                      , and\n                      <jats:italic>HPSE<\/jats:italic>\n                      genes can cause disturbance in the ECM environment of AB and promote bone resorption.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14697","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T13:35:29Z","timestamp":1690464929000},"page":"2362-2372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extracellular matrix of ameloblastoma\u2010derived negatively regulates osteogenic differentiation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-9046","authenticated-orcid":false,"given":"Hongrong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Stomatology Hospital of Kunming Medical University  Kunming China"},{"name":"Yunnan Key Laboratory of Stomatology  Kunming 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