{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:48:24Z","timestamp":1747187304115,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The association of migraine with the risk of certain cancer has been reported. The aim of this pilot study was to examine the associations between migraine and the onset of head and neck cancers (HNC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 1755 individuals were identified through a nationwide population\u2010based cohort registry in Taiwan between 2000 and 2013. The primary end point variable was new\u2010onset head and neck cancers in patients with migraine versus non\u2010migraine controls. Cox proportional hazard regression was used to derive the risk of HNC. Subgroup analyses were performed to determine subpopulations at risk of migraine\u2010associated HNC. Sub\u2010outcome analyses were carried out to provide the subtypes of migraine\u2010associated HNC. Propensity score matching was utilized to validate the findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of four patients out of 351 patients with migraine and seven out of 1404 non\u2010migraine controls developed HNC. The incidence of HNC was higher in patients with migraine than that in non\u2010migraine controls (108.93 vs. 48.77 per 100,000 person\u2010years) (adjusted hazard ratio, aHR\u2009=\u20092.908, 95% CI\u2009=\u20090.808\u201310.469; <jats:italic>p<\/jats:italic>\u2009=\u20090.102). The risk of HNC in patients with migraine with aura (aHR\u2009=\u20095.454, 95% CI\u2009=\u20090.948\u201326.875; <jats:italic>p<\/jats:italic>\u2009=\u20090.264) and without aura (aHR\u2009=\u20092.777, 95% CI\u2009=\u20090.755\u20138.473; <jats:italic>p<\/jats:italic>\u2009=\u20090.118) was revealed. The incidence of non\u2010nasopharyngeal HNC secondary to migraine (112.79 per 100,000 person\u2010years) was higher than that of nasopharyngeal cancer secondary to migraine (105.33 per 100,000 person\u2010years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A higher incidence of HNC was observed in a small sample of patients with migraine, especially in those with migraine with aura. Migraine\u2010associated HNC included non\u2010nasopharyngeal HNC. Studies with a larger sample are needed to confirm the finding of the high risk of HNC in people with migraine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14704","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T11:21:44Z","timestamp":1691493704000},"page":"2122-2135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Migraine and subsequent head and neck cancer: A nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"30","author":[{"given":"Li\u2010Tzu","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0512-477X","authenticated-orcid":false,"given":"Ping\u2010Hao","family":"Chiang","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Hsiang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medical Research Tri\u2010Service General Hospital  Taipei Taiwan"},{"name":"National Defense Medical Center Graduate Institute of Life Sciences  Taipei Taiwan"},{"name":"Taiwanese Injury Prevention and Safety Promotion Association  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Clinical and Translational Epidemiology Unit Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Gastroenterology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sait","family":"Ashina","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Anesthesia, Critical Care and Pain Medicine Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"},{"name":"Beth Israel Deaconess Medical Center Comprehensive Headache Center, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Chien","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Medical Research Tri\u2010Service General Hospital  Taipei Taiwan"},{"name":"National Defense Medical Center Graduate Institute of Life Sciences  Taipei Taiwan"},{"name":"Taiwanese Injury Prevention and Safety Promotion Association  Taipei Taiwan"},{"name":"National Defense Medical Center, School of Public Health  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-4144","authenticated-orcid":false,"given":"Kevin Sheng\u2010Kai","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Center for Global Health, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Orthodontics and Dentofacial Orthopedics, Henry M. Goldman School of Dental Medicine Boston University  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010018\u20100902\u2010y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1715715"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21588"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353559"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21343"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277\u20109175.148297"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201084102\u20102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.752563"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12851"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102982.2007.01405.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010015\u20100501\u20100"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12468"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0423"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201009\u20100291"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjab050"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21\u20100256"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10121537"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14115"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21\u20100215"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2010.01792.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201008\u20100527"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01550\u20106"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672\u2010012\u20100117\u20107"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31062"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2015.1045868"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105403"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012701"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000379741"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010012\u20100092\u2010x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju381"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020632"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238242"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.03.013"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T10:03:48Z","timestamp":1718100228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.14704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,8]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/odi.14704"],"URL":"https:\/\/doi.org\/10.1111\/odi.14704","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"type":"print","value":"1354-523X"},{"type":"electronic","value":"1601-0825"}],"subject":[],"published":{"date-parts":[[2023,8,8]]},"assertion":[{"value":"2022-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}