{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:00:02Z","timestamp":1783454402212,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diosgenin, an essential dietary steroidal sapogenin, possess multiple pharmacological activities. This study aimed to assess the effects of diosgenin on periodontitis and elucidate the mechanisms. Lipopolysaccharide (LPS)\u2010stimulated human periodontal ligament stem cells (hPDLCs) and a\n                    <jats:italic>Porphyromonas gingivalis (P.g)<\/jats:italic>\n                    plus ligation\u2010induced animal model were used for in vitro and in vivo studies, respectively. Inflammatory responses, nuclear factor \u03ba\u2010B (NF\u2010\u03baB) signaling and osteogenesis\u2010related markers were measured both in LPS\u2010stimulated hPDLSCs and in gingival tissue of periodontitis rats. Treatment with diosgenin significantly inhibited the production of tumor necrosis factor \u03b1 (TNF\u2010\u03b1), interleukin (IL)\u20101\u03b2, and interleukin (IL)\u20106 and the activation of NF\u2010\u03baB pathway in LPS\u2010stimulated hPDLSCs. Further, treatment with diosgenin enhanced the expression of osteoblast\u2010related genes and increased the osteogenic differentiation capacity. Further, activation NF\u2010\u03baB pathway largely abolished the protective effects of diosgenin. Consistent with the in vitro studies, in vivo studies showed that administering diosgenin to periodontitis rats significantly lowered the levels of the TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 and the inflammatory transcription factor NF\u2010\u03baB in gingival tissue. In addition, osteoblast\u2010related genes were promoted. Diosgenin attenuates periodontitis by adjusting NF\u2010\u03baB signaling to inhibit inflammatory effects and promoting osteogenesis, suggesting diosgenin might be developed as a therapeutic strategy for treating periodontitis in the future.\n                  <\/jats:p>","DOI":"10.1111\/odi.14708","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:28:22Z","timestamp":1692624502000},"page":"2497-2510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Diosgenin prevents periodontitis by inhibiting inflammation and promoting osteogenic differentiation"],"prefix":"10.1111","volume":"30","author":[{"given":"Shaohua","family":"Cong","sequence":"first","affiliation":[{"name":"Department of Stomatology Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences  Shanghai 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