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The obtained results are validated through established histological methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Discrimination of osteonecrosis from physiological tissues was evaluated at 119 distinct measurement loci in 40 surgical specimens from 28 patients. Mean Raman spectra were refined from 11,900 raw spectra, and characteristic peaks were assigned to their respective molecular origin. Then, following principal component and linear discriminant analyses, osteonecrotic lesions were distinguished from physiological tissue entities, such as viable bone, with a sensitivity, specificity, and overall accuracy of 100%. Moreover, bone mineral content, quality, maturity, and crystallinity were quantified, revealing an increased mineral\u2010to\u2010matrix ratio and decreased carbonate\u2010to\u2010phosphate ratio in ARONJ lesions compared to physiological bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results demonstrate feasibility with high classification accuracy in this collective. The differentiation was determined by the spectral features of the organic and mineral composition of bone. This merely optical, noninvasive technique is a promising candidate to ameliorate both the diagnosis and treatment of ARONJ in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14721","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T08:40:52Z","timestamp":1693471252000},"page":"2439-2452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Raman spectroscopy and <scp>U<\/scp>\u2010Net deep neural network in antiresorptive drug\u2010related osteonecrosis of the jaw"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-4428","authenticated-orcid":false,"given":"Levi","family":"Matthies","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Mildred Scheel Cancer Career Center HaTriCS4 University Medical Center Hamburg\u2010Eppendorf  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