{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:41:32Z","timestamp":1778611292980,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T00:00:00Z","timestamp":1693699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270995"],"award-info":[{"award-number":["82270995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970956"],"award-info":[{"award-number":["81970956"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62177040"],"award-info":[{"award-number":["62177040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate and explain the beneficial effects of local intra\u2010articular injection of Salubrinal on temporomandibular joint osteoarthritis (TMJOA) using a rabbit model of anterior disc displacement (ADD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rabbits were divided and subjected to surgical ADD. Salubrinal was administered by intra\u2010articular injection in the TMJ every other day for 2 and 4\u2009weeks after operation. Histological examination and TUNEL staining were then performed. Immunohistochemistry, quantitative real\u2010time PCR, and Western blot analysis were employed to evaluate the expression of endoplasmic reticulum (ER) stress\u2010related markers, catabolic factors, extracellular matrix proteins, inflammatory factors, and nuclear factor\u2010kappa B (NF\u2010\u03baB) activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the ADD groups, we found that Salubrinal partly reversed condylar cartilage deterioration according to the histological analysis. Salubrinal reduced chondrocytes apoptosis while increased matrix components including Collagen II and Aggrecan. Meanwhile, Salubrinal downregulated the catabolic expression of MMP13, ADAMTS5, VEGF, TNF\u2010\u03b1, and IL\u20101\u03b2. We also observed that Salubrinal inhibited ER stress activation by reducing the expression of GRP78, CHOP, ATF4, and Caspase\u201012. Additionally, Salubrinal suppressed the phosphorylation of NF\u2010\u03baB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that Salubrinal alleviates cartilage degradation following ADD, suggesting that intra\u2010articular injection of Salubrinal is a potential therapeutic approach for preventing TMJOA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14731","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T20:00:10Z","timestamp":1693771210000},"page":"2453-2462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Salubrinal alleviates cartilage degradation in a rabbit temporomandibular joint osteoarthritis model"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-6916","authenticated-orcid":false,"given":"Ting","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Stomatology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shuai","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8410-1906","authenticated-orcid":false,"given":"Mengjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101902"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010171"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.03.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2002.34414"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.02.657"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.01.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046\u20103758.45.2000378"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.09.021"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9827312"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.407296"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20102159\u2010z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010016\u20101070\u20106"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.2010.00920.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.80"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12016"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/47513"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1527"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109880"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010017\u20101296\u2010y"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1179\/2042618613Y.0000000060"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.086"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.08.004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0311\u2010184"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102613.2010.00758.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418\u2010005\u20100773\u20106"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700406"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17041"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073501"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155514"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12715"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010016\u20102933\u20105"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1606647"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010015\u20100536\u20107"}],"container-title":["Oral 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