{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:09:05Z","timestamp":1774339745557,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study investigated the effects of\n                      <jats:italic>Lactobacillus fermentum<\/jats:italic>\n                      BELF11 on periodontitis in mice (LIP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty mice were randomly assigned to a control group (CTL), LIP\/PBS group (LIP and PBS applied), or LIP\/BELF11 group (LIP and\n                      <jats:italic>L. fermentum<\/jats:italic>\n                      BELF11 applied). For 14\u2009days, PBS or\n                      <jats:italic>L. fermentum<\/jats:italic>\n                      BELF11 was applied twice daily to the mice in the LIP\/PBS or LIP\/BELF11 group, respectively. After 14\u2009days, radiographic, histological, and pro\u2010inflammatory cytokine assessments were conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The LIP\/PBS and LIP\/BELF11 groups demonstrated greater alveolar bone loss than the CTL group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The LIP\/BELF11 group showed significantly reduced alveolar bone loss on the mesial side compared to the LIP\/PBS group. Histologically, the LIP\/BELF11 group showed consistent patterns of connective tissue fiber arrangement, lower levels of inflammatory infiltration, less alveolar bone loss, and higher alveolar bone density than the LIP\/PBS group, despite showing more signs of destruction than the CTL group. The LIP\/BELF11 group also exhibited significantly lower levels of pro\u2010inflammatory cytokines than the LIP\/PBS group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>L. fermentum<\/jats:italic>\n                      BELF11 inhibits alveolar bone loss and periodontitis progression by regulating pro\u2010inflammatory cytokine production. These findings suggest that\n                      <jats:italic>L. fermentum<\/jats:italic>\n                      BELF11 may be a potential adjunctive therapy in periodontal treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14739","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T05:06:52Z","timestamp":1695100012000},"page":"3328-3335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Lactobacillus fermentum<\/i>\n                    attenuates the alveolar bone loss in ligature\u2010induced periodontitis in mice"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-1786","authenticated-orcid":false,"given":"Yuni","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Periodontology and Research Institute of Oral Sciences Gangneung\u2010Wonju National University College of Dentistry  Gangneung Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2283-6066","authenticated-orcid":false,"given":"Bo Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Research Institute of Oral Sciences Gangneung\u2010Wonju National University College of Dentistry  Gangneung Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-275X","authenticated-orcid":false,"given":"Ki\u2010Yeon","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Research Institute of Oral Sciences Gangneung\u2010Wonju National University College of Dentistry  Gangneung Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-7941","authenticated-orcid":false,"given":"Hye Ji","family":"Lim","sequence":"additional","affiliation":[{"name":"R&amp;D Center, Hecto Healthcare Co., Ltd  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8372-9312","authenticated-orcid":false,"given":"Kum\u2010Joo","family":"Shin","sequence":"additional","affiliation":[{"name":"R&amp;D Center, Hecto Healthcare Co., Ltd  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-1580","authenticated-orcid":false,"given":"Jae\u2010Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Research Institute of Oral Sciences Gangneung\u2010Wonju National University College of Dentistry  Gangneung Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1998.00480.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12608"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01109.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2020-19625"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.00073.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2000.tb00118.x"},{"key":"e_1_2_10_8_1","first-page":"82","article-title":"Local drug delivery systems in the treatment of periodontitis: A literature review","volume":"17","author":"Rocha J\u00fanior H. 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