{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:20:39Z","timestamp":1790565639243,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730030"],"award-info":[{"award-number":["81730030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771081"],"award-info":[{"award-number":["81771081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was aimed to evaluate the safety and benefit of short\u2010term application of hydroxychloroquine in the management of atrophic\/erosive\/ulcerative oral lichen planus (OLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter, randomized, controlled, evaluator\u2010blinded, prospective clinical trial was performed from October 1, 2019, to September 1, 2022. A total of 99 patients were randomized to receive systemic use of hydroxychloroquine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950), or topical use of 0.05% dexamethasone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949) for 4\u2009weeks. The response to both treatment modalities was evaluated according to reticulation, hyperemic, and ulceration (RHU) score and visual analog scale (VAS) score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 4\u2009weeks of medication, both groups showed substantial reduction in RHU and VAS score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In hydroxychloroquine group, the average of RHU score was reduced from 10.60 to 7.68 (dropped 27.49%), and the average of VAS score was reduced from 3.74 to 2.47 (dropped 34.09%). There were no differences between the two groups in reduction of RHU score and VAS score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Single factor analysis found hyperemic area (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019) and erosive\/ulcerative area (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024) had impacts on drug efficacy of hydroxychloroquine, and logistic regression revealed that no factors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) influenced its efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate hydroxychloroquine is a safe and effective agent in treating atrophic\/erosive\/ulcerative OLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14746","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:30:56Z","timestamp":1696519856000},"page":"3126-3135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hydroxychloroquine is effective in oral lichen planus: A multicenter, randomized, controlled trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-2281","authenticated-orcid":false,"given":"Yulang","family":"Xie","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-1460","authenticated-orcid":false,"given":"Yufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology National Clinical Research Center of Stomatology  Shanghai 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